@article{7b724e04db514d5e8cf9de870f6d3553,
title = "Inhibition of mitochondrial metabolism by (−)-jerantinine A: synthesis and biological studies in triple-negative breast cancer cells",
abstract = "A concise semi-synthesis of the Aspidosperma alkaloids, (−)-jerantinine A and (−)-melodinine P, and derivatives thereof, is reported. The novel compounds were shown to have potent activity against MDA-MB-231 triple-negative breast cancer cells. Furthermore, unbiased metabolomics and live cell reporter assays reveal (−)-jerantinine A alters cellular redox metabolism and induces oxidative stress that coincides with cell cycle arrest.",
author = "Gialelis, {Timothy L.} and Zifei Wang and Homer, {Joshua A.} and Yang, {Wen Hsuan} and Taemoon Chung and Qingting Hu and Smedley, {Christopher J.} and Pawar, {Nitin J.} and Upadhyay, {Nitinkumar S.} and Tuveson, {David A.} and Lyons, {Scott K.} and Lukey, {Michael J.} and Moses, {John E.}",
note = "Funding Information: The current work was financially supported by the NCI Cancer Center Support Grant 5P30CA045508 and by the Cold Spring Harbor Laboratory Northwell Health Affiliation. We thank The F. M. Kirby Foundation (J. E. M.), Sunshine Foundation (J. E. M.), S. J. Edwards (J. E. M.), The Starr Foundation (J. E. M.), The Wasily Family Foundation (J. E. M.), METAvivor (M. J. L., W.-H. Y.), The Elsa U. Pardee Foundation (M. J. L.), the Department of Defense Breast Cancer Research Program BC200599 (M. J. L.), and La Trobe University (J. E. M.) for generous support. This work was performed with assistance from the CSHL Mass Spectrometry and Metabolomics and CSHL Animal Imaging Shared Resources, which are supported in part by the Cancer Center Support Grant 5P30CA045508. Publisher Copyright: {\textcopyright} 2023 RSC.",
year = "2023",
month = apr,
day = "1",
doi = "10.1039/d3md00049d",
language = "English",
volume = "14",
pages = "710--714",
journal = "RSC Medicinal Chemistry",
issn = "2632-8682",
publisher = "The Royal Society of Chemistry",
number = "4",
}
