Inhibition of mitochondrial metabolism by (−)-jerantinine A: synthesis and biological studies in triple-negative breast cancer cells

Timothy L. Gialelis, Zifei Wang, Joshua A. Homer, Wen Hsuan Yang, Taemoon Chung, Qingting Hu, Christopher J. Smedley, Nitin J. Pawar, Nitinkumar S. Upadhyay, David A. Tuveson, Scott K. Lyons, Michael J. Lukey, John E. Moses

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)


A concise semi-synthesis of the Aspidosperma alkaloids, (−)-jerantinine A and (−)-melodinine P, and derivatives thereof, is reported. The novel compounds were shown to have potent activity against MDA-MB-231 triple-negative breast cancer cells. Furthermore, unbiased metabolomics and live cell reporter assays reveal (−)-jerantinine A alters cellular redox metabolism and induces oxidative stress that coincides with cell cycle arrest.

Original languageEnglish
Pages (from-to)710-714
Number of pages5
JournalRSC Medicinal Chemistry
Issue number4
Publication statusPublished - 1 Apr 2023
Externally publishedYes

Cite this