Inhibition of long-term memory formation in the chicken by anti chick Thy-1 antibody

C. C A Bernard, M. E. Gibbs, R. J. Hodge, K. T. Ng

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6 Citations (Scopus)


Anti-chick Thy-1 antibodies administered close to a single trial passive avoidance learning task in day-old chicks resulted in inhibition of long-term memory formation. The retention time course was comparable to that obtained with the protein synthesis inhibitor anisomycin. The amnestic effect of the anti-chick Thy-1 antibody appears to be mediated solely by immunoglobulin G, and is species specific since anti-rat Thy-1 antibodies did not produce amnesia. The results are consistent with a three stage model of memory formation, suggest a role for glycoproteins in long term memory formation, and emphasise the potential of neuroimmunological tools for investigating the neurological bases of memory formation.

Original languageEnglish
Pages (from-to)111-116
Number of pages6
JournalBrain Research Bulletin
Issue number1
Publication statusPublished - 1983
Externally publishedYes


  • Anti chick Thy-1 antibody
  • Glycoproteins
  • Immunoglobulin G
  • Long-term memory
  • Neuroimmunology

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