Inhibition of ice crystal growth by synthetic glycopolymers: Implications for the rational design of antifreeze glycoprotein mimics

Matthew I. Gibson, Carl A. Barker, Sebastian G. Spain, Luca Albertin, Neil R. Cameron

Research output: Contribution to journalArticleResearchpeer-review

74 Citations (Scopus)

Abstract

A series of structurally diverse polymers, containing either peptide or vinyl-derived backbones, was tested for ice recrystallization inhibition activity, which is commonly associated with antifreeze (glyco)proteins. It was revealed that only polymers bearing hydroxyl groups in the side chain could inhibit ice growth. Furthermore, well-defined glycopolymers were shown to have a small but significant recrystallization inhibition effect, showing that it may be possible to design antifreeze glycoprotein mimics based upon polymers derived from vinyl monomers. copyright

Original languageEnglish
Pages (from-to)328-333
Number of pages6
JournalBiomacromolecules
Volume10
Issue number2
DOIs
Publication statusPublished - 9 Feb 2009
Externally publishedYes

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