Inhibition of death receptor signaling by bacterial gut pathogens

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33 Citations (Scopus)

Abstract

Gastrointestinal bacterial pathogens such as enteropathogenic Escherichia coli, Salmonella and Shigella control inflammatory and apoptotic signaling in human intestinal cells to establish infection, replicate and disseminate to other hosts. These pathogens manipulate host cell signaling through the translocation of virulence effector proteins directly into the host cell cytoplasm, which then target various signaling pathways. Death receptors such as TNFR1, FAS and TRAIL-R induce signaling cascades that are crucial to the clearance of pathogens, and as such are major targets for inhibition by pathogens. This review focuses on what is known about how bacterial gut pathogens inhibit death receptor signaling to suppress inflammation and prevent apoptosis.

Original languageEnglish
Pages (from-to)235-243
Number of pages9
JournalCytokine and Growth Factor Reviews
Volume25
Issue number2
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Apoptosis
  • Bacterial pathogens
  • Death receptor
  • Inflammation
  • T3SS effectors

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