TY - JOUR
T1 - Inhibition of death receptor signaling by bacterial gut pathogens
AU - Giogha, Cristina
AU - Lung, Tania Wong Fok
AU - Pearson, Jaclyn S.
AU - Hartland, Elizabeth L.
PY - 2014
Y1 - 2014
N2 - Gastrointestinal bacterial pathogens such as enteropathogenic Escherichia coli, Salmonella and Shigella control inflammatory and apoptotic signaling in human intestinal cells to establish infection, replicate and disseminate to other hosts. These pathogens manipulate host cell signaling through the translocation of virulence effector proteins directly into the host cell cytoplasm, which then target various signaling pathways. Death receptors such as TNFR1, FAS and TRAIL-R induce signaling cascades that are crucial to the clearance of pathogens, and as such are major targets for inhibition by pathogens. This review focuses on what is known about how bacterial gut pathogens inhibit death receptor signaling to suppress inflammation and prevent apoptosis.
AB - Gastrointestinal bacterial pathogens such as enteropathogenic Escherichia coli, Salmonella and Shigella control inflammatory and apoptotic signaling in human intestinal cells to establish infection, replicate and disseminate to other hosts. These pathogens manipulate host cell signaling through the translocation of virulence effector proteins directly into the host cell cytoplasm, which then target various signaling pathways. Death receptors such as TNFR1, FAS and TRAIL-R induce signaling cascades that are crucial to the clearance of pathogens, and as such are major targets for inhibition by pathogens. This review focuses on what is known about how bacterial gut pathogens inhibit death receptor signaling to suppress inflammation and prevent apoptosis.
KW - Apoptosis
KW - Bacterial pathogens
KW - Death receptor
KW - Inflammation
KW - T3SS effectors
UR - http://www.scopus.com/inward/record.url?scp=84899047370&partnerID=8YFLogxK
U2 - 10.1016/j.cytogfr.2013.12.012
DO - 10.1016/j.cytogfr.2013.12.012
M3 - Short Survey
C2 - 24440054
AN - SCOPUS:84899047370
SN - 1359-6101
VL - 25
SP - 235
EP - 243
JO - Cytokine and Growth Factor Reviews
JF - Cytokine and Growth Factor Reviews
IS - 2
ER -