Inhibition by serum of experimental autoimmune orchitis (EAO) was studied in guinea pigs. It was found that the capacity of an autoantigen, antigen P, purified from guinea pigs spermatozoa, to produce lesions of EAO could be inhibited by mixing antigen P with a small amount of normal human serum before injection into guinea pigs. In protected animals, cell mediated immunity and humoral antibodies to antigen P were also significantly suppressed.
|Number of pages||6|
|Journal||Australian Journal of Experimental Biology and Medical Science|
|Publication status||Published - 1975|