Inhibited fragmentation of mAbs in buffered ionic liquids

Romiza Rehana Mazid, Vijayaraghavan Ranganathan, Douglas Robert Macfarlane, Christina Cortez-Jugo, Wenlong Cheng

Research output: Contribution to journalArticleOtherpeer-review

Abstract

We thoroughly investigated the biological, structural and chemical stability of epidermal growth factor receptor monoclonal antibody (EGFR mAb) using choline-based buffered ionic liquids (BILs). The results demonstrated substantially enhanced stabilities in our BILs, indicating their huge promise as real-world green biological buffers for antibody storage and transportation.
Original languageEnglish
Pages (from-to)8089 - 8092
Number of pages4
JournalChemical Communications
Volume51
Issue number38
DOIs
Publication statusPublished - 2015

Cite this

Mazid, Romiza Rehana ; Ranganathan, Vijayaraghavan ; Macfarlane, Douglas Robert ; Cortez-Jugo, Christina ; Cheng, Wenlong. / Inhibited fragmentation of mAbs in buffered ionic liquids. In: Chemical Communications. 2015 ; Vol. 51, No. 38. pp. 8089 - 8092.
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Inhibited fragmentation of mAbs in buffered ionic liquids. / Mazid, Romiza Rehana; Ranganathan, Vijayaraghavan; Macfarlane, Douglas Robert; Cortez-Jugo, Christina; Cheng, Wenlong.

In: Chemical Communications, Vol. 51, No. 38, 2015, p. 8089 - 8092.

Research output: Contribution to journalArticleOtherpeer-review

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AU - Cheng, Wenlong

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AB - We thoroughly investigated the biological, structural and chemical stability of epidermal growth factor receptor monoclonal antibody (EGFR mAb) using choline-based buffered ionic liquids (BILs). The results demonstrated substantially enhanced stabilities in our BILs, indicating their huge promise as real-world green biological buffers for antibody storage and transportation.

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