Inhibited fragmentation of mAbs in buffered ionic liquids

Romiza Rehana Mazid; Vijayaraghavan Ranganathan; Douglas Robert Macfarlane; Christina Cortez-Jugo; Wenlong Cheng

doi:10.1039/c5cc01877c

Inhibited fragmentation of mAbs in buffered ionic liquids

Romiza Rehana Mazid, Vijayaraghavan Ranganathan, Douglas Robert Macfarlane, Christina Cortez-Jugo, Wenlong Cheng

Research output: Contribution to journal › Article › Other › peer-review

11 Citations (Scopus)

Abstract

We thoroughly investigated the biological, structural and chemical stability of epidermal growth factor receptor monoclonal antibody (EGFR mAb) using choline-based buffered ionic liquids (BILs). The results demonstrated substantially enhanced stabilities in our BILs, indicating their huge promise as real-world green biological buffers for antibody storage and transportation.

Original language	English
Pages (from-to)	8089 - 8092
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	38
DOIs	https://doi.org/10.1039/c5cc01877c
Publication status	Published - 2015

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10.1039/c5cc01877c

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Cite this

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title = "Inhibited fragmentation of mAbs in buffered ionic liquids",

abstract = "We thoroughly investigated the biological, structural and chemical stability of epidermal growth factor receptor monoclonal antibody (EGFR mAb) using choline-based buffered ionic liquids (BILs). The results demonstrated substantially enhanced stabilities in our BILs, indicating their huge promise as real-world green biological buffers for antibody storage and transportation.",

author = "Mazid, {Romiza Rehana} and Vijayaraghavan Ranganathan and Macfarlane, {Douglas Robert} and Christina Cortez-Jugo and Wenlong Cheng",

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T1 - Inhibited fragmentation of mAbs in buffered ionic liquids

AU - Mazid, Romiza Rehana

AU - Ranganathan, Vijayaraghavan

AU - Macfarlane, Douglas Robert

AU - Cortez-Jugo, Christina

AU - Cheng, Wenlong

PY - 2015

Y1 - 2015

N2 - We thoroughly investigated the biological, structural and chemical stability of epidermal growth factor receptor monoclonal antibody (EGFR mAb) using choline-based buffered ionic liquids (BILs). The results demonstrated substantially enhanced stabilities in our BILs, indicating their huge promise as real-world green biological buffers for antibody storage and transportation.

AB - We thoroughly investigated the biological, structural and chemical stability of epidermal growth factor receptor monoclonal antibody (EGFR mAb) using choline-based buffered ionic liquids (BILs). The results demonstrated substantially enhanced stabilities in our BILs, indicating their huge promise as real-world green biological buffers for antibody storage and transportation.

UR - http://pubs.rsc.org.ezproxy.lib.monash.edu.au/en/content/articlepdf/2015/cc/c5cc01877c

U2 - 10.1039/c5cc01877c

DO - 10.1039/c5cc01877c

M3 - Article

VL - 51

SP - 8089

EP - 8092

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 38

ER -