TY - JOUR
T1 - Inhibited fragmentation of mAbs in buffered ionic liquids
AU - Mazid, Romiza Rehana
AU - Ranganathan, Vijayaraghavan
AU - Macfarlane, Douglas Robert
AU - Cortez-Jugo, Christina
AU - Cheng, Wenlong
PY - 2015
Y1 - 2015
N2 - We thoroughly investigated the biological, structural and chemical stability of epidermal growth factor receptor monoclonal antibody (EGFR mAb) using choline-based buffered ionic liquids (BILs). The results demonstrated substantially enhanced stabilities in our BILs, indicating their huge promise as real-world green biological buffers for antibody storage and transportation.
AB - We thoroughly investigated the biological, structural and chemical stability of epidermal growth factor receptor monoclonal antibody (EGFR mAb) using choline-based buffered ionic liquids (BILs). The results demonstrated substantially enhanced stabilities in our BILs, indicating their huge promise as real-world green biological buffers for antibody storage and transportation.
UR - http://pubs.rsc.org.ezproxy.lib.monash.edu.au/en/content/articlepdf/2015/cc/c5cc01877c
U2 - 10.1039/c5cc01877c
DO - 10.1039/c5cc01877c
M3 - Article
VL - 51
SP - 8089
EP - 8092
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 38
ER -