Inhibited fragmentation of mAbs in buffered ionic liquids

Romiza Rehana Mazid, Vijayaraghavan Ranganathan, Douglas Robert Macfarlane, Christina Cortez-Jugo, Wenlong Cheng

Research output: Contribution to journalArticleOtherpeer-review

11 Citations (Scopus)

Abstract

We thoroughly investigated the biological, structural and chemical stability of epidermal growth factor receptor monoclonal antibody (EGFR mAb) using choline-based buffered ionic liquids (BILs). The results demonstrated substantially enhanced stabilities in our BILs, indicating their huge promise as real-world green biological buffers for antibody storage and transportation.
Original languageEnglish
Pages (from-to)8089 - 8092
Number of pages4
JournalChemical Communications
Volume51
Issue number38
DOIs
Publication statusPublished - 2015

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