Ingibin i rak iaichnikov.

Translated title of the contribution: Inhibin and ovarian cancer

H. G. Burger, A. Baillie, A. E. Drummond, D. L. Healy, T. Jobling, P. Mamers, D. M. Robertson, B. Susil, N. Cahir, Y. Shen, K. Verity, P. J. Fuller, N. P. Groome, J. K. Findlay

Research output: Contribution to journalArticleOther

2 Citations (Scopus)

Abstract

Previous observations from our laboratory have demonstrated that the levels of immunoreactive inhibin (ir-inh) are elevated in almost all patients with granulosa cell tumors and in the majority of postmenopausal women with mucinous ovarian cancers. The present report confirms these findings in a larger group of post-menopausal women. Immunohistochemistry for the inhibin alpha. beta A and beta B sununits shows predominantly epithelial staining in granulosa cell tumors and in the majority of mucinous cancers. Serous cystadenocarcinomas also frequently show positive staining. Studies seeking to identify G alpha i-2 or FSH receptor mutations have provided negative results in contrast to other reports. Further studies of the roles of the inhibin-related family of peptides in ovarian cancer diagnosis and monitoring are clearly indicated.

Translated title of the contributionInhibin and ovarian cancer
Original languageRussian
Pages (from-to)369-373
Number of pages5
JournalVoprosy Onkologii
Volume45
Issue number4
Publication statusPublished - 1999
Externally publishedYes

Cite this

Burger, H. G., Baillie, A., Drummond, A. E., Healy, D. L., Jobling, T., Mamers, P., Robertson, D. M., Susil, B., Cahir, N., Shen, Y., Verity, K., Fuller, P. J., Groome, N. P., & Findlay, J. K. (1999). Ingibin i rak iaichnikov. Voprosy Onkologii, 45(4), 369-373.