Inhibin a-subunit gene expression in the ovaries of immature female rats is stimulated by pregnant mare serum gonadotrophin

Susan R. Davis; Fiona Dench; Irene Nikolaidis; Judith A. Clements; Robert G. Forage; Zygmunt Krozowski; Henry G. Burger

doi:10.1016/S0006-291X(86)80408-9

Inhibin a-subunit gene expression in the ovaries of immature female rats is stimulated by pregnant mare serum gonadotrophin

Susan R. Davis, Fiona Dench, Irene Nikolaidis, Judith A. Clements, Robert G. Forage, Zygmunt Krozowski, Henry G. Burger

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

We have used a bovine cDNA probe for the A-subunit of inhibin to demonstrate the presence of inhibin in the ovaries of immature female rats: the levels of mRNA were increased following treatment of the rats with pregnant mare serum gonadotrophin (PMSG), suggesting modulation by PMSG of ovarian inhibin synthesis at least at the level of transcription. Furthermore, we report the unexpected finding of significant levels of inhibin mRNA in the corpora lutea of mature female rats. No inhibin mRNA was demonstrable in the uterus or placenta.

Original language	English
Pages (from-to)	1191-1195
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	138
Issue number	3
DOIs	https://doi.org/10.1016/S0006-291X(86)80408-9
Publication status	Published - 14 Aug 1986
Externally published	Yes

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title = "Inhibin a-subunit gene expression in the ovaries of immature female rats is stimulated by pregnant mare serum gonadotrophin",

abstract = "We have used a bovine cDNA probe for the A-subunit of inhibin to demonstrate the presence of inhibin in the ovaries of immature female rats: the levels of mRNA were increased following treatment of the rats with pregnant mare serum gonadotrophin (PMSG), suggesting modulation by PMSG of ovarian inhibin synthesis at least at the level of transcription. Furthermore, we report the unexpected finding of significant levels of inhibin mRNA in the corpora lutea of mature female rats. No inhibin mRNA was demonstrable in the uterus or placenta.",

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AU - Davis, Susan R.

AU - Dench, Fiona

AU - Nikolaidis, Irene

AU - Clements, Judith A.

AU - Forage, Robert G.

AU - Krozowski, Zygmunt

AU - Burger, Henry G.

PY - 1986/8/14

Y1 - 1986/8/14

N2 - We have used a bovine cDNA probe for the A-subunit of inhibin to demonstrate the presence of inhibin in the ovaries of immature female rats: the levels of mRNA were increased following treatment of the rats with pregnant mare serum gonadotrophin (PMSG), suggesting modulation by PMSG of ovarian inhibin synthesis at least at the level of transcription. Furthermore, we report the unexpected finding of significant levels of inhibin mRNA in the corpora lutea of mature female rats. No inhibin mRNA was demonstrable in the uterus or placenta.

AB - We have used a bovine cDNA probe for the A-subunit of inhibin to demonstrate the presence of inhibin in the ovaries of immature female rats: the levels of mRNA were increased following treatment of the rats with pregnant mare serum gonadotrophin (PMSG), suggesting modulation by PMSG of ovarian inhibin synthesis at least at the level of transcription. Furthermore, we report the unexpected finding of significant levels of inhibin mRNA in the corpora lutea of mature female rats. No inhibin mRNA was demonstrable in the uterus or placenta.

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Inhibin a-subunit gene expression in the ovaries of immature female rats is stimulated by pregnant mare serum gonadotrophin

Abstract

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