Inhibin A and pro-αC inhibin in Down syndrome and normal pregnancies

Donato D'Antona, Euan M. Wallace, Catherine Shearing, J. Peter Ashby, Nigel P. Groome

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Using two enzyme-linked immunosorbent assays specific for inhibin A and pro-αC inhibin, levels of the two proteins were assessed in maternal serum from 43 Down syndrome and 300 chromosomally normal pregnancies at 15-17 weeks' gestation. Compared to the control pregnancies, both inhibin A and pro-αC inhibin were significantly elevated in the Down syndrome pregnancies with median levels, expressed as multiples of the normal median, of 1.53 MoM and 1.34 MoM, respectively (P < 0.001 and P = 0.046 compared to controls). Levels of inhibin A and pro-αC inhibin were weakly but significantly correlated in both the control and the Down syndrome sera (r = 0.25, P < 0.0001; r = 0.4, P = 0.008, respectively). These data suggest that the mechanism(s) underlying the elevated inhibin levels observed in Down syndrome may affect the regulation of both the inhibin α- and β(A)-subunits.

Original languageEnglish
Pages (from-to)1122-1126
Number of pages5
JournalPrenatal Diagnosis
Issue number11
Publication statusPublished - 1 Nov 1998


  • Down syndrome
  • Inhibin
  • Prenatal screening

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