Abstract
Nitric oxide 10 ppm and inhaled aerosolized prostacyclin 50 ng/kg/min were compared as selective pulmonary vasodilators in five patients with hypoxaemia secondary to acute respiratory distress syndrome. Neither agent resulted in systemic haemodynamic changes, indicating true pulmonary selectivity. Inhaled aerolized prostacyclin improved oxygenation to a degree comparable to nitric oxide, as measured by the arterial alveolar oxygen partial pressure gradient and shunt fraction.
| Original language | English |
|---|---|
| Pages (from-to) | 564-568 |
| Number of pages | 5 |
| Journal | Anaesthesia and Intensive Care |
| Volume | 24 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1996 |
| Externally published | Yes |
Keywords
- Lung: acute respiratoiy distress syndrome, vasodilator prostacyclin, nitric oxide