Ingibin i rak iaichnikov.

H. G. Burger; A. Baillie; A. E. Drummond; D. L. Healy; T. Jobling; P. Mamers; D. M. Robertson; B. Susil; N. Cahir; Y. Shen; K. Verity; P. J. Fuller; N. P. Groome; J. K. Findlay

Ingibin i rak iaichnikov.

Translated title of the contribution: Inhibin and ovarian cancer

H. G. Burger, A. Baillie, A. E. Drummond, D. L. Healy, T. Jobling, P. Mamers, D. M. Robertson, B. Susil, N. Cahir, Y. Shen, K. Verity, P. J. Fuller, N. P. Groome, J. K. Findlay

Research output: Contribution to journal › Article › Other

2 Citations (Scopus)

Abstract

Previous observations from our laboratory have demonstrated that the levels of immunoreactive inhibin (ir-inh) are elevated in almost all patients with granulosa cell tumors and in the majority of postmenopausal women with mucinous ovarian cancers. The present report confirms these findings in a larger group of post-menopausal women. Immunohistochemistry for the inhibin alpha. beta A and beta B sununits shows predominantly epithelial staining in granulosa cell tumors and in the majority of mucinous cancers. Serous cystadenocarcinomas also frequently show positive staining. Studies seeking to identify G alpha i-2 or FSH receptor mutations have provided negative results in contrast to other reports. Further studies of the roles of the inhibin-related family of peptides in ovarian cancer diagnosis and monitoring are clearly indicated.

Translated title of the contribution	Inhibin and ovarian cancer
Original language	Russian
Pages (from-to)	369-373
Number of pages	5
Journal	Voprosy Onkologii
Volume	45
Issue number	4
Publication status	Published - 1999
Externally published	Yes

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Cite this

@article{4cd42acda8ca4f64900f9e64933db4f8,

title = "Ingibin i rak iaichnikov.",

abstract = "Previous observations from our laboratory have demonstrated that the levels of immunoreactive inhibin (ir-inh) are elevated in almost all patients with granulosa cell tumors and in the majority of postmenopausal women with mucinous ovarian cancers. The present report confirms these findings in a larger group of post-menopausal women. Immunohistochemistry for the inhibin alpha. beta A and beta B sununits shows predominantly epithelial staining in granulosa cell tumors and in the majority of mucinous cancers. Serous cystadenocarcinomas also frequently show positive staining. Studies seeking to identify G alpha i-2 or FSH receptor mutations have provided negative results in contrast to other reports. Further studies of the roles of the inhibin-related family of peptides in ovarian cancer diagnosis and monitoring are clearly indicated.",

author = "Burger, {H. G.} and A. Baillie and Drummond, {A. E.} and Healy, {D. L.} and T. Jobling and P. Mamers and Robertson, {D. M.} and B. Susil and N. Cahir and Y. Shen and K. Verity and Fuller, {P. J.} and Groome, {N. P.} and Findlay, {J. K.}",

year = "1999",

language = "Russian",

volume = "45",

pages = "369--373",

journal = "Voprosy Onkologii",

issn = "0507-3758",

publisher = "Izdatel'stvo Eskulap",

number = "4",

}

TY - JOUR

T1 - Ingibin i rak iaichnikov.

AU - Burger, H. G.

AU - Baillie, A.

AU - Drummond, A. E.

AU - Healy, D. L.

AU - Jobling, T.

AU - Mamers, P.

AU - Robertson, D. M.

AU - Susil, B.

AU - Cahir, N.

AU - Shen, Y.

AU - Verity, K.

AU - Fuller, P. J.

AU - Groome, N. P.

AU - Findlay, J. K.

PY - 1999

Y1 - 1999

N2 - Previous observations from our laboratory have demonstrated that the levels of immunoreactive inhibin (ir-inh) are elevated in almost all patients with granulosa cell tumors and in the majority of postmenopausal women with mucinous ovarian cancers. The present report confirms these findings in a larger group of post-menopausal women. Immunohistochemistry for the inhibin alpha. beta A and beta B sununits shows predominantly epithelial staining in granulosa cell tumors and in the majority of mucinous cancers. Serous cystadenocarcinomas also frequently show positive staining. Studies seeking to identify G alpha i-2 or FSH receptor mutations have provided negative results in contrast to other reports. Further studies of the roles of the inhibin-related family of peptides in ovarian cancer diagnosis and monitoring are clearly indicated.

AB - Previous observations from our laboratory have demonstrated that the levels of immunoreactive inhibin (ir-inh) are elevated in almost all patients with granulosa cell tumors and in the majority of postmenopausal women with mucinous ovarian cancers. The present report confirms these findings in a larger group of post-menopausal women. Immunohistochemistry for the inhibin alpha. beta A and beta B sununits shows predominantly epithelial staining in granulosa cell tumors and in the majority of mucinous cancers. Serous cystadenocarcinomas also frequently show positive staining. Studies seeking to identify G alpha i-2 or FSH receptor mutations have provided negative results in contrast to other reports. Further studies of the roles of the inhibin-related family of peptides in ovarian cancer diagnosis and monitoring are clearly indicated.

UR - http://www.scopus.com/inward/record.url?scp=0032670750&partnerID=8YFLogxK

M3 - Article

C2 - 10532093

AN - SCOPUS:0032670750

SN - 0507-3758

VL - 45

SP - 369

EP - 373

JO - Voprosy Onkologii

JF - Voprosy Onkologii

IS - 4

ER -

Ingibin i rak iaichnikov.

Abstract

UN SDGs

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Research output

Inhibin and ovarian cancer

Cite this