Infrapatellar fat pad in the knee: is local fat good or bad for knee osteoarthritis?

Weiyu Han, Shiji Cai, Zhenhua Liu, Xingzhong Jin, Xia Wang, Benny Antony, Yuelong Cao, Dawn Aitken, Flavia Maria Cicuttini, Graeme Jones, Changhai Ding

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Abstract

Introduction: Recent studies regarding the infrapatellar fat pad (IPFP) mainly focus on the roles of the cells derived from the IPFP. There have been few clinical or epidemiological studies reporting on the association between the IPFP and knee osteoarthritis (OA). Our objective is to generate hypotheses regarding the associations between IPFP maximum area and knee OA measures in older adults.Methods: A total of 977 subjects between 50 and 80 years of age (mean, 62.4 years) participated in the study. Radiographic knee osteophyte and joint space narrowing (JSN) were assessed using the Osteoarthritis Research Society International atlas. T1- or T2-weighted fat suppressed magnetic resonance imaging (MRI) was utilized to assess IPFP maximum area, cartilage volume, cartilage defects, and bone marrow lesions (BMLs). Knee pain was assessed by self-administered Western Ontario McMaster Osteoarthritis Index (WOMAC) questionnaire.Results: After adjustment for potential confounders, IPFP maximum area was significantly associated with joint space narrowing (odds ratio (OR): 0.75, 95 confidence interval (CI): 0.62 to 0.91 (medial), 0.77, 95 CI: 0.62 to 0.96 (lateral)) and medial osteophytes (OR: 0.52, 95 CI: 0.35 to 0.76), knee tibial and patellar cartilage volume (?: 56.9 to 164.9 mm3/cm2, all P
Original languageEnglish
Pages (from-to)1 - 8
Number of pages8
JournalArthritis Research & Therapy
Volume16
Issue number4 (Art. No.: R145)
DOIs
Publication statusPublished - 2014

Cite this

Han, W., Cai, S., Liu, Z., Jin, X., Wang, X., Antony, B., Cao, Y., Aitken, D., Cicuttini, F. M., Jones, G., & Ding, C. (2014). Infrapatellar fat pad in the knee: is local fat good or bad for knee osteoarthritis? Arthritis Research & Therapy, 16(4 (Art. No.: R145)), 1 - 8. https://doi.org/10.1186/ar4607