TY - JOUR
T1 - Influenza virus and cell signaling pathways
AU - Gaur, Pratibha
AU - Munjal, Ashok
AU - Lal, Sunil K.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2011
Y1 - 2011
N2 - Summary Influenza viruses comprise a major class of human respiratory pathogens, responsible for causing morbidity and mortality worldwide. Influenza A virus, due to its segmented RNA genome, is highly subject to mutation, resulting in rapid formation of variants. During influenza infection, viral proteins interact with host proteins and exploit a variety of cellular pathways for their own benefit. Influenza virus inhibits the synthesis of these cellular proteins and facilitates expression of its own proteins for viral transcription and replication. Infected cell pathways are hijacked by an array of intracellular signaling cascades such as NF-κB signaling, PI3K/Akt pathway, MAPK pathway, PKC/PKR signaling and TLR/RIG-I signaling cascades. This review presents a research update on the subject and discusses the impact of influenza viral infection on these cell signaling pathways.
AB - Summary Influenza viruses comprise a major class of human respiratory pathogens, responsible for causing morbidity and mortality worldwide. Influenza A virus, due to its segmented RNA genome, is highly subject to mutation, resulting in rapid formation of variants. During influenza infection, viral proteins interact with host proteins and exploit a variety of cellular pathways for their own benefit. Influenza virus inhibits the synthesis of these cellular proteins and facilitates expression of its own proteins for viral transcription and replication. Infected cell pathways are hijacked by an array of intracellular signaling cascades such as NF-κB signaling, PI3K/Akt pathway, MAPK pathway, PKC/PKR signaling and TLR/RIG-I signaling cascades. This review presents a research update on the subject and discusses the impact of influenza viral infection on these cell signaling pathways.
KW - Cellular signaling (NF-κB, PI3K/AKT, MAPK, PKC/PKR, TLR/RIG-I signaling)
KW - Influenza virus
UR - http://www.scopus.com/inward/record.url?scp=79958755726&partnerID=8YFLogxK
U2 - 10.12659/MSM.881801
DO - 10.12659/MSM.881801
M3 - Review Article
AN - SCOPUS:79958755726
SN - 1234-1010
VL - 17
SP - RA148-RA154
JO - Medical Science Monitor
JF - Medical Science Monitor
IS - 6
ER -