Influenza vaccine effectiveness against hospitalizations associated with influenza A(H3N2) in Hong Kong children aged 9 months to 17 years, June-November 2023

Caitriona Murphy; Mike Y.W. Kwan; Eunice L.Y. Chan; Joshua S.C. Wong; Sheena G. Sullivan; Malik Peiris; Benjamin J. Cowling; So Lun Lee

doi:10.1016/j.vaccine.2024.02.056

Influenza vaccine effectiveness against hospitalizations associated with influenza A(H3N2) in Hong Kong children aged 9 months to 17 years, June-November 2023

Caitriona Murphy, Mike Y.W. Kwan, Eunice L.Y. Chan, Joshua S.C. Wong, Sheena G. Sullivan, Malik Peiris, Benjamin J. Cowling, So Lun Lee

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Abstract

A test negative study was carried out from 13 June through to 15 November 2023 enrolling 3183 children hospitalized with acute respiratory illness in Hong Kong. Influenza A and B viruses were detected in 528 (16.6%) children, among which 419 (79.4%) were influenza A(H3N2). The overall vaccine effectiveness against hospitalization associated with any influenza virus infection was estimated as 22.4% (95% CI: −11.7%, 46.1%), and against influenza A(H3N2) specifically was 14.3% (95% CI: −29.2%, 43.2%). Despite the moderate to low VE estimated here, which could be a result of waning immunity and antigenic drift, influenza vaccination remains an important approach to reduce the impact of influenza in children.

Original language	English
Pages (from-to)	1878-1882
Number of pages	5
Journal	Vaccine
Volume	42
Issue number	8
DOIs	https://doi.org/10.1016/j.vaccine.2024.02.056
Publication status	Published - 19 Mar 2024
Externally published	Yes

Keywords

H3N2
Influenza
Vaccination
Vaccine effectiveness

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2024.02.056

Cite this

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title = "Influenza vaccine effectiveness against hospitalizations associated with influenza A(H3N2) in Hong Kong children aged 9 months to 17 years, June-November 2023",

abstract = "A test negative study was carried out from 13 June through to 15 November 2023 enrolling 3183 children hospitalized with acute respiratory illness in Hong Kong. Influenza A and B viruses were detected in 528 (16.6%) children, among which 419 (79.4%) were influenza A(H3N2). The overall vaccine effectiveness against hospitalization associated with any influenza virus infection was estimated as 22.4% (95% CI: −11.7%, 46.1%), and against influenza A(H3N2) specifically was 14.3% (95% CI: −29.2%, 43.2%). Despite the moderate to low VE estimated here, which could be a result of waning immunity and antigenic drift, influenza vaccination remains an important approach to reduce the impact of influenza in children.",

keywords = "H3N2, Influenza, Vaccination, Vaccine effectiveness",

author = "Caitriona Murphy and Kwan, {Mike Y.W.} and Chan, {Eunice L.Y.} and Wong, {Joshua S.C.} and Sullivan, {Sheena G.} and Malik Peiris and Cowling, {Benjamin J.} and Lee, {So Lun}",

note = "Funding Information: The authors thank Julie Au for technical support. This research was supported by the Health and Medical Research Fund, Health Bureau, The Government of the Hong Kong Special Administrative Region (grant no. INF-HKU-3). BJC is supported by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services , under contract no. 75N93021C00015, the Theme-based Research Scheme (Project No. T11-712/19-N) of the Research Grants Council of the Hong Kong SAR Government , and an RGC Senior Research Fellowship from the University Grants Committee (grant number: HKU SRFS2021-7S03). Publisher Copyright: {\textcopyright} 2024",

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doi = "10.1016/j.vaccine.2024.02.056",

language = "English",

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T1 - Influenza vaccine effectiveness against hospitalizations associated with influenza A(H3N2) in Hong Kong children aged 9 months to 17 years, June-November 2023

AU - Murphy, Caitriona

AU - Kwan, Mike Y.W.

AU - Chan, Eunice L.Y.

AU - Wong, Joshua S.C.

AU - Sullivan, Sheena G.

AU - Peiris, Malik

AU - Cowling, Benjamin J.

AU - Lee, So Lun

N1 - Funding Information: The authors thank Julie Au for technical support. This research was supported by the Health and Medical Research Fund, Health Bureau, The Government of the Hong Kong Special Administrative Region (grant no. INF-HKU-3). BJC is supported by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services , under contract no. 75N93021C00015, the Theme-based Research Scheme (Project No. T11-712/19-N) of the Research Grants Council of the Hong Kong SAR Government , and an RGC Senior Research Fellowship from the University Grants Committee (grant number: HKU SRFS2021-7S03). Publisher Copyright: © 2024

PY - 2024/3/19

Y1 - 2024/3/19

N2 - A test negative study was carried out from 13 June through to 15 November 2023 enrolling 3183 children hospitalized with acute respiratory illness in Hong Kong. Influenza A and B viruses were detected in 528 (16.6%) children, among which 419 (79.4%) were influenza A(H3N2). The overall vaccine effectiveness against hospitalization associated with any influenza virus infection was estimated as 22.4% (95% CI: −11.7%, 46.1%), and against influenza A(H3N2) specifically was 14.3% (95% CI: −29.2%, 43.2%). Despite the moderate to low VE estimated here, which could be a result of waning immunity and antigenic drift, influenza vaccination remains an important approach to reduce the impact of influenza in children.

AB - A test negative study was carried out from 13 June through to 15 November 2023 enrolling 3183 children hospitalized with acute respiratory illness in Hong Kong. Influenza A and B viruses were detected in 528 (16.6%) children, among which 419 (79.4%) were influenza A(H3N2). The overall vaccine effectiveness against hospitalization associated with any influenza virus infection was estimated as 22.4% (95% CI: −11.7%, 46.1%), and against influenza A(H3N2) specifically was 14.3% (95% CI: −29.2%, 43.2%). Despite the moderate to low VE estimated here, which could be a result of waning immunity and antigenic drift, influenza vaccination remains an important approach to reduce the impact of influenza in children.

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KW - Vaccine effectiveness

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Influenza vaccine effectiveness against hospitalizations associated with influenza A(H3N2) in Hong Kong children aged 9 months to 17 years, June-November 2023

Abstract

Keywords

UN SDGs

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