Influenza vaccine effectiveness against hospitalisation with influenza in adults in Australia in 2014

Allen Cheuk-Seng Cheng, Anastase Thomas Christos Kotsimbos, Paul M Kelly, FluCAN Investigators, Tony M Korman

Research output: Contribution to journalArticleResearchpeer-review

Abstract

We provide estimates of the influenza vaccine protection against hospitalisation with laboratory-confirmed influenza in the 2014 Australian season where the A/H1N1/pdm09 strain predominated. This was performed using a case-test negative study design as part of a national sentinel surveillance system in Australia. Vaccine effectiveness was estimated as (1-OR). ?. 100 where the odds ratio of vaccination in cases vs test negative participants was estimated from a conditional logistic regression. Between April and November, 1692 adult patients were admitted with laboratory-confirmed influenza. Vaccine effectiveness was estimated from 1283 patients with influenza and 1116 test negative patients where vaccination status was ascertained. Vaccination was associated with a reduction in the risk of hospitalisation with influenza of 51.5 (95 CI: 41.6 , 59.7 ) in all patients, and a reduction of 50.7 (95 CI: 40.1 , 59.3 ) in the target population for vaccination. We estimate that the influenza vaccine was moderately protective against hospitalisation with laboratory-confirmed influenza during the 2014 influenza season in Australia.
Original languageEnglish
Pages (from-to)7352 - 7356
Number of pages5
JournalVaccine
Volume33
Issue number51
DOIs
Publication statusPublished - 16 Dec 2015

Cite this

Cheng, Allen Cheuk-Seng ; Kotsimbos, Anastase Thomas Christos ; Kelly, Paul M ; FluCAN Investigators ; Korman, Tony M. / Influenza vaccine effectiveness against hospitalisation with influenza in adults in Australia in 2014. In: Vaccine. 2015 ; Vol. 33, No. 51. pp. 7352 - 7356.
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abstract = "We provide estimates of the influenza vaccine protection against hospitalisation with laboratory-confirmed influenza in the 2014 Australian season where the A/H1N1/pdm09 strain predominated. This was performed using a case-test negative study design as part of a national sentinel surveillance system in Australia. Vaccine effectiveness was estimated as (1-OR). ?. 100 where the odds ratio of vaccination in cases vs test negative participants was estimated from a conditional logistic regression. Between April and November, 1692 adult patients were admitted with laboratory-confirmed influenza. Vaccine effectiveness was estimated from 1283 patients with influenza and 1116 test negative patients where vaccination status was ascertained. Vaccination was associated with a reduction in the risk of hospitalisation with influenza of 51.5 (95 CI: 41.6 , 59.7 ) in all patients, and a reduction of 50.7 (95 CI: 40.1 , 59.3 ) in the target population for vaccination. We estimate that the influenza vaccine was moderately protective against hospitalisation with laboratory-confirmed influenza during the 2014 influenza season in Australia.",
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Influenza vaccine effectiveness against hospitalisation with influenza in adults in Australia in 2014. / Cheng, Allen Cheuk-Seng; Kotsimbos, Anastase Thomas Christos; Kelly, Paul M; FluCAN Investigators ; Korman, Tony M.

In: Vaccine, Vol. 33, No. 51, 16.12.2015, p. 7352 - 7356.

Research output: Contribution to journalArticleResearchpeer-review

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