Influential factors in optic nerve head biomechanics

Chai Yee Loke, Ean Hin Ooi

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther


Irreversible damage of the optic nerve bundles is the major concern in the study of glaucomatous optic neuropathy. In the efforts of developing a complete diagnostic system, it is essential to investigate the most dominant factors in optic nerve head biomechanics. A three-dimensional human eye model is developed in COMSOL Multiphy sics® for computational finite element analysis. A full-scale sensitivity analysis is carried out considering 14 input factors. A preliminary screening is done using Morris method [8] to determine the top 5 influential factors. Subsequently, linear and nonlinear effects of the top 5 factors are ranked by analysis of variance. Numerical results suggest that apart from intraocular pressure, scleral stiffness may remain the most dominant factor in biomechanical response of the lamina cribrosa as reported in previous studies [11, 17,18, 20, 23], followed by stiffness of the post-laminar neural tissue.

Original languageEnglish
Title of host publicationInternational Conference on Numerical Analysis and Applied Mathematics, ICNAAM 2019
EditorsTheodore E. Simos, Charalambos Tsitouras
PublisherAmerican Institute of Physics
ISBN (Electronic)9780735440258
Publication statusPublished - 24 Nov 2020
EventInternational Conference on Numerical Analysis and Applied Mathematics (ICNAAM) 2019 - Rhodes, Greece
Duration: 23 Sept 201928 Sept 2019 (Proceedings)

Publication series

NameAIP Conference Proceedings
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616


ConferenceInternational Conference on Numerical Analysis and Applied Mathematics (ICNAAM) 2019
Abbreviated titleICNAAM 2019
Internet address

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