Influence of the MCT1 rs1049434 on Indirect Muscle Disorders/Injuries in Elite Football Players

Myosotis Massidda; Nir Eynon; Valeria Bachis; Laura Corrias; Claudia Culigioni; Francesco Piras; Paolo Cugia; Marco Scorcu; Carla M. Calò

doi:10.1186/s40798-015-0033-9

Influence of the MCT1 rs1049434 on Indirect Muscle Disorders/Injuries in Elite Football Players

Myosotis Massidda, Nir Eynon, Valeria Bachis, Laura Corrias, Claudia Culigioni, Francesco Piras, Paolo Cugia, Marco Scorcu, Carla M. Calò

Research output: Contribution to journal › Article › Research › peer-review

31 Citations (Scopus)

Abstract

Background: The aim of this study was to investigate the association between MCT1 rs1049434 polymorphism and indirect muscle injuries in elite football players. One hundred and seventy-three male elite Italian football players (age = 19.2 ± 5.3 years) were recruited from a first-league football club participating at the Official National Italian Football Championship (Serie A, Primavera, Allievi, Giovanissimi). The cohort was genotyped for the MCT1 rs1049434 polymorphism, and muscle injuries data were collected during the period of 2009–2014 (five football seasons). Methods: Genomic DNA was extracted using a buccal swab, and genotyping was performed using PCR method. Structural-mechanical injuries and functional muscle disorder were included in the acute indirect muscle injury group. Results: Participants with the MCT1 AA (AA = 1.57 ± 3.07, n = 69) genotype exhibit significantly higher injury incidents compared to participants with the TT genotype (TT = 0.09 ± 0.25, n = 22, P = 0.04). Conclusions: The MCT1 rs1049434 polymorphism is associated with the incidence of muscle injuries in elite football players. We anticipate that the knowledge of athletes’ genetic predisposition to sports-related injuries might aid in individualizing training programs.

Original language	English
Article number	33
Number of pages	6
Journal	Sports Medicine - Open
Volume	1
Issue number	1
DOIs	https://doi.org/10.1186/s40798-015-0033-9
Publication status	Published - 1 Dec 2015
Externally published	Yes

Keywords

Elite athletes
Football
Genetic association
Lactate
Monocarboxylate transporter-1
Muscle injuries

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10.1186/s40798-015-0033-9Licence: CC BY

Cite this

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abstract = "Background: The aim of this study was to investigate the association between MCT1 rs1049434 polymorphism and indirect muscle injuries in elite football players. One hundred and seventy-three male elite Italian football players (age = 19.2 ± 5.3 years) were recruited from a first-league football club participating at the Official National Italian Football Championship (Serie A, Primavera, Allievi, Giovanissimi). The cohort was genotyped for the MCT1 rs1049434 polymorphism, and muscle injuries data were collected during the period of 2009–2014 (five football seasons). Methods: Genomic DNA was extracted using a buccal swab, and genotyping was performed using PCR method. Structural-mechanical injuries and functional muscle disorder were included in the acute indirect muscle injury group. Results: Participants with the MCT1 AA (AA = 1.57 ± 3.07, n = 69) genotype exhibit significantly higher injury incidents compared to participants with the TT genotype (TT = 0.09 ± 0.25, n = 22, P = 0.04). Conclusions: The MCT1 rs1049434 polymorphism is associated with the incidence of muscle injuries in elite football players. We anticipate that the knowledge of athletes{\textquoteright} genetic predisposition to sports-related injuries might aid in individualizing training programs.",

keywords = "Elite athletes, Football, Genetic association, Lactate, Monocarboxylate transporter-1, Muscle injuries",

author = "Myosotis Massidda and Nir Eynon and Valeria Bachis and Laura Corrias and Claudia Culigioni and Francesco Piras and Paolo Cugia and Marco Scorcu and Cal{\`o}, {Carla M.}",

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AU - Massidda, Myosotis

AU - Eynon, Nir

AU - Bachis, Valeria

AU - Corrias, Laura

AU - Culigioni, Claudia

AU - Piras, Francesco

AU - Cugia, Paolo

AU - Scorcu, Marco

AU - Calò, Carla M.

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KW - Elite athletes

KW - Football

KW - Genetic association

KW - Lactate

KW - Monocarboxylate transporter-1

KW - Muscle injuries

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Influence of the MCT1 rs1049434 on Indirect Muscle Disorders/Injuries in Elite Football Players

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Keywords

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