Influence of single nucleotide polymorphisms in COMT , MAO-A and BDNF genes on dyskinesias and levodopa use in Parkinson's disease

Perdita Anne Cheshire; Kelly Bertram; Helen Ling; Sean S O'Sullivan; Glenda M Halliday; Catriona Ann McLean; Jose Bras; Tom Foltynie; Elsdon Storey; David Williams

doi:10.1159/000351097

Influence of single nucleotide polymorphisms in COMT , MAO-A and BDNF genes on dyskinesias and levodopa use in Parkinson's disease

Perdita Anne Cheshire, Kelly Bertram, Helen Ling, Sean S O'Sullivan, Glenda M Halliday, Catriona Ann McLean, Jose Bras, Tom Foltynie, Elsdon Storey, David Williams

Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

57 Citations (Scopus)

Abstract

BACKGROUND: Clinical heterogeneity in the development of levodopa-induced dyskinesias (LID) suggests endogenous factors play a significant role in determining their overall prevalence. OBJECTIVE: We hypothesised that single nucleotide polymorphisms (SNPs) in specific genes may result in a clinical phenotype conducive to an increased risk of LID.

Original language	English
Pages (from-to)	24 - 28
Number of pages	5
Journal	Neurodegenerative Diseases
Volume	13
Issue number	1
DOIs	https://doi.org/10.1159/000351097
Publication status	Published - 2014

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abstract = "BACKGROUND: Clinical heterogeneity in the development of levodopa-induced dyskinesias (LID) suggests endogenous factors play a significant role in determining their overall prevalence. OBJECTIVE: We hypothesised that single nucleotide polymorphisms (SNPs) in specific genes may result in a clinical phenotype conducive to an increased risk of LID.",

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AU - Cheshire, Perdita Anne

AU - Bertram, Kelly

AU - Ling, Helen

AU - O'Sullivan, Sean S

AU - Halliday, Glenda M

AU - McLean, Catriona Ann

AU - Bras, Jose

AU - Foltynie, Tom

AU - Storey, Elsdon

AU - Williams, David

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Clinical heterogeneity in the development of levodopa-induced dyskinesias (LID) suggests endogenous factors play a significant role in determining their overall prevalence. OBJECTIVE: We hypothesised that single nucleotide polymorphisms (SNPs) in specific genes may result in a clinical phenotype conducive to an increased risk of LID.

AB - BACKGROUND: Clinical heterogeneity in the development of levodopa-induced dyskinesias (LID) suggests endogenous factors play a significant role in determining their overall prevalence. OBJECTIVE: We hypothesised that single nucleotide polymorphisms (SNPs) in specific genes may result in a clinical phenotype conducive to an increased risk of LID.

UR - http://www.karger.com/Article/Pdf/351097

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DO - 10.1159/000351097

M3 - Article

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JO - Neurodegenerative Diseases

JF - Neurodegenerative Diseases

IS - 1

ER -

Influence of single nucleotide polymorphisms in COMT , MAO-A and BDNF genes on dyskinesias and levodopa use in Parkinson's disease

Abstract

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