Influence of single nucleotide polymorphisms in COMT , MAO-A and BDNF genes on dyskinesias and levodopa use in Parkinson's disease

Perdita Anne Cheshire, Kelly Bertram, Helen Ling, Sean S O'Sullivan, Glenda M Halliday, Catriona Ann McLean, Jose Bras, Tom Foltynie, Elsdon Storey, David Williams

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29 Citations (Scopus)

Abstract

BACKGROUND: Clinical heterogeneity in the development of levodopa-induced dyskinesias (LID) suggests endogenous factors play a significant role in determining their overall prevalence. OBJECTIVE: We hypothesised that single nucleotide polymorphisms (SNPs) in specific genes may result in a clinical phenotype conducive to an increased risk of LID.
Original languageEnglish
Pages (from-to)24 - 28
Number of pages5
JournalNeurodegenerative Diseases
Volume13
Issue number1
DOIs
Publication statusPublished - 2014

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