Influence of parity and sexual history on cytomegalovirus seroprevalence among women aged 20–49 years in the USA

Tatiana M Lanzieri, Deanna Kruszon-Moran, Manoj Gambhir, Stephanie R Bialek

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Objective To assess the influence of parity, as a proxy for exposure to children, and sexual history on cytomegalovirus (CMV) seroprevalence. Methods Data were retrospectively analyzed from women aged 20–49 years who were tested for CMV immunoglobulin G antibodies in the 1999–2004 National Health and Nutrition Examination Survey, a nationally representative survey of the US population. Logistic regression was used to determine independent variables associated with CMV seroprevalence. Results Among 3710 women, the age-adjusted CMV seroprevalence was 61.3% (95% CI 58.9%–63.6%). In age-adjusted univariate analysis, women who had given birth at least once had higher overall CMV seroprevalence (66.0%, 95% CI 63.1%–68.9%) than did those who had not given birth (49.0%, 95% CI 44.4%–53.7%; P < 0.001). In multivariate logistic analysis, higher CMV seroprevalence was independently associated with number of live births (each additional birth: adjusted odds ratio [aOR] 1.2, 95% CI 1.1–1.3), age at first sexual intercourse (< 18 vs ≥ 18 years: aOR 1.3, 95% CI 1.1–1.6), lifetime sexual partners (≥ 10 vs < 10: aOR 1.4, 95% CI 1.1–1.9), and herpes type 2 seropositivity (aOR 1.9, 95% CI 1.5–2.6) after controlling for age, race/Hispanic origin, place of birth, poverty index, and education. Conclusion Among US women of reproductive age, parity and sexual exposures were independently associated with increased CMV seroprevalence.

Original languageEnglish
Pages (from-to)82-85
Number of pages4
JournalInternational Journal of Gynecology and Obstetrics
Issue number1
Publication statusPublished - 1 Oct 2016


  • Cytomegalovirus
  • Parity
  • Reproductive age
  • Seroprevalence

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