TY - JOUR
T1 - Influence of ispaghula and zein coating on ibuprofen-loaded alginate beads prepared by vibration technology
T2 - Physicochemical characterization and release studies
AU - Heng, Jillian Jin Lyn
AU - Teng, Jia Hao
AU - Saravanan, Muniyandy
AU - Pushpamalar, Janarthanan
N1 - Funding Information:
Acknowledgments: The work was supported by the seed grant (BCHH-SS-5-02-2010) given by Monash University, Malaysia. The author thanks Ching Huey, Mettler Toledo, Shah Alam, Selangor, Malaysia, for performing DSC analysis.
Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/6
Y1 - 2018/6
N2 - The purpose behind the work was to fabricate alginate beads with better drug loading and extended drug release. Ispaghula was used to enhance the drug loading while zein was employed to extend the drug release. Ibuprofen was employed as a model drug in this study. Ibuprofen-loaded alginate beads with and without ispaghula were prepared using vibration technology and coated with zein. The beads prepared with alginate alone were shown to have loading and entrapment efficiencies of 35% and 70% w/w, respectively. Addition of ispaghula in alginate showed a significant increase (p < 0.05) in the drug loading (42% w/w) and entrapment efficiency (84% w/w). Fourier-transform infrared spectroscopy confirmed the presence of ispaghula and zein coating in the alginate beads as well as the ibuprofen loading. Scanning electron microscopy revealed better spherical geometry in the beads with ispaghula. The surface morphology of the uncoated beads was rough due to crystalline and surface drug. The zein coating has produced a smoother surface and particle adhesion. Differential scanning calorimetry has shown a reduction in drug crystallinity. Alginate beads extended the drug release for 4 h and the presence of zein extended the release for 6 h.
AB - The purpose behind the work was to fabricate alginate beads with better drug loading and extended drug release. Ispaghula was used to enhance the drug loading while zein was employed to extend the drug release. Ibuprofen was employed as a model drug in this study. Ibuprofen-loaded alginate beads with and without ispaghula were prepared using vibration technology and coated with zein. The beads prepared with alginate alone were shown to have loading and entrapment efficiencies of 35% and 70% w/w, respectively. Addition of ispaghula in alginate showed a significant increase (p < 0.05) in the drug loading (42% w/w) and entrapment efficiency (84% w/w). Fourier-transform infrared spectroscopy confirmed the presence of ispaghula and zein coating in the alginate beads as well as the ibuprofen loading. Scanning electron microscopy revealed better spherical geometry in the beads with ispaghula. The surface morphology of the uncoated beads was rough due to crystalline and surface drug. The zein coating has produced a smoother surface and particle adhesion. Differential scanning calorimetry has shown a reduction in drug crystallinity. Alginate beads extended the drug release for 4 h and the presence of zein extended the release for 6 h.
KW - Alginate beads
KW - Coating
KW - Ispaghula
KW - Microencapsulation
KW - Vibration technology
KW - Zein
UR - http://www.scopus.com/inward/record.url?scp=85051012510&partnerID=8YFLogxK
U2 - 10.3390/scipharm86020024
DO - 10.3390/scipharm86020024
M3 - Article
C2 - 29874858
AN - SCOPUS:85051012510
SN - 2218-0532
VL - 86
JO - Scientia Pharmaceutica
JF - Scientia Pharmaceutica
IS - 2
M1 - 24
ER -