TY - JOUR
T1 - Influence of gastric acid on susceptibility to infection with ingested bacterial pathogens
AU - Tennant, Sharon M
AU - Hartland, Elizabeth Louise
AU - Phumoonna, Tongted
AU - Lyras, Dena
AU - Rood, Julian Ian
AU - Robins-Browne, Roy Michael
AU - van Driel, Ian R
PY - 2008
Y1 - 2008
N2 - Despite the widely held belief that gastric acid serves as a barrier to bacterial pathogens, there are almost no experimental data to support this hypothesis. We have developed a mouse model to quantify the effectiveness of gastric acid in mediating resistance to infection with ingested bacteria. Mice that were constitutively hypochlorhydric due to a mutation in a gastric H(+)/K(+)-ATPase (proton pump) gene were infected with Yersinia enterocolitica, Salmonella enterica serovar Typhimurium, Citrobacter rodentium or Clostridium perfringens cells or spores. Significantly greater numbers of Yersinia, Salmonella and Citrobacter cells (P
AB - Despite the widely held belief that gastric acid serves as a barrier to bacterial pathogens, there are almost no experimental data to support this hypothesis. We have developed a mouse model to quantify the effectiveness of gastric acid in mediating resistance to infection with ingested bacteria. Mice that were constitutively hypochlorhydric due to a mutation in a gastric H(+)/K(+)-ATPase (proton pump) gene were infected with Yersinia enterocolitica, Salmonella enterica serovar Typhimurium, Citrobacter rodentium or Clostridium perfringens cells or spores. Significantly greater numbers of Yersinia, Salmonella and Citrobacter cells (P
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18025100
M3 - Article
SN - 0019-9567
VL - 76
SP - 639
EP - 645
JO - Infection and Immunity
JF - Infection and Immunity
ER -