Inflammatory regulators of redirected neural migration in the injured brain

Nicole Bye, Ann M Turnley, Maria Cristina Morganti-Kossmann

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Brain injury following stroke or trauma induces the migration of neuroblasts derived from subventricular zone neural precursor cells (NPCs) towards the damaged tissue, where they then have the potential to contribute to repair. Enhancing the recruitment of new cells thus presents an enticing prospect for the development of new therapeutic approaches to treat brain injury; to this end, an understanding of the factors regulating this process is required. During the neuroinflammatory response to ischemic and traumatic brain injuries, a plethora of pro- and anti-inflammatory cytokines, chemokines and growth factors are released in the damaged tissue, and recent work indicates that a variety of these are able to influence injury-induced migration. In this review, we will discuss the contribution of specific chemokines and growth factors towards stimulating NPC migration in the injured brain.
Original languageEnglish
Pages (from-to)132 - 146
Number of pages15
JournalNeurosignals
Volume20
Issue number3
DOIs
Publication statusPublished - 2012

Cite this

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title = "Inflammatory regulators of redirected neural migration in the injured brain",
abstract = "Brain injury following stroke or trauma induces the migration of neuroblasts derived from subventricular zone neural precursor cells (NPCs) towards the damaged tissue, where they then have the potential to contribute to repair. Enhancing the recruitment of new cells thus presents an enticing prospect for the development of new therapeutic approaches to treat brain injury; to this end, an understanding of the factors regulating this process is required. During the neuroinflammatory response to ischemic and traumatic brain injuries, a plethora of pro- and anti-inflammatory cytokines, chemokines and growth factors are released in the damaged tissue, and recent work indicates that a variety of these are able to influence injury-induced migration. In this review, we will discuss the contribution of specific chemokines and growth factors towards stimulating NPC migration in the injured brain.",
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Inflammatory regulators of redirected neural migration in the injured brain. / Bye, Nicole; Turnley, Ann M; Morganti-Kossmann, Maria Cristina.

In: Neurosignals, Vol. 20, No. 3, 2012, p. 132 - 146.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Inflammatory regulators of redirected neural migration in the injured brain

AU - Bye, Nicole

AU - Turnley, Ann M

AU - Morganti-Kossmann, Maria Cristina

PY - 2012

Y1 - 2012

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AB - Brain injury following stroke or trauma induces the migration of neuroblasts derived from subventricular zone neural precursor cells (NPCs) towards the damaged tissue, where they then have the potential to contribute to repair. Enhancing the recruitment of new cells thus presents an enticing prospect for the development of new therapeutic approaches to treat brain injury; to this end, an understanding of the factors regulating this process is required. During the neuroinflammatory response to ischemic and traumatic brain injuries, a plethora of pro- and anti-inflammatory cytokines, chemokines and growth factors are released in the damaged tissue, and recent work indicates that a variety of these are able to influence injury-induced migration. In this review, we will discuss the contribution of specific chemokines and growth factors towards stimulating NPC migration in the injured brain.

U2 - 10.1159/000336542

DO - 10.1159/000336542

M3 - Article

VL - 20

SP - 132

EP - 146

JO - Neurosignals

JF - Neurosignals

SN - 1424-862X

IS - 3

ER -