Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites

Kerstin Sarter, Manuel Kulagin, Georg Schett, Nicola L. Harris, Mario M. Zaiss

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)


Infections with different helminth species have been observed to ameliorate a variety of chronic inflammatory diseases. Herein, we show that the natural murine helminth species, Heligmosomoides polygyrus bakeri (Hp) is capable of attenuating disease severity in two different inflammatory arthritis models. Furthermore, we show that excretory–secretory (ES) products from Hp directly suppress osteoclast differentiation in vitro. Taken together, these results demonstrate that helminth infections can dampen autoimmune diseases and highlight a previously unrecognized and important role for ES products, by directly impacting on bone destruction.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
Issue number3
Publication statusPublished - 3 Apr 2017
Externally publishedYes


  • Arthritis
  • bone metabolism
  • excretory–secretory products
  • helminths
  • osteoclast

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