Inflammation-induced foam cell formation in chronic inflammatory disease

Thomas A. Angelovich, Anna C. Hearps, Anthony Jaworowski

Research output: Contribution to journalReview ArticleOtherpeer-review

33 Citations (Scopus)

Abstract

Atherosclerosis is the leading cause of cardiovascular disease and is both a metabolic and inflammatory disease. Two models describe early events initiating atherosclerotic plaque formation, whereby foam cells form in response to hyperlipidaemia or inflammation-associated stimuli. Although these models are inextricably linked and not mutually exclusive, identifying the unique contribution of each in different disease settings remains an important question. Circulating monocytes are key mediators of atherogenesis in both models as precursors to lipid-laden foam cells formed in response to either excess lipid deposition in arteries, signalling via pattern-associated molecular patterns or a combination of the two. In this review, we assess the role of monocytes in each model and discuss how key steps in atherogenesis may be targeted to enhance clinical outcomes in patients with chronic inflammatory disease.

Original languageEnglish
Pages (from-to)683-693
Number of pages11
JournalImmunology and Cell Biology
Volume93
Issue number8
DOIs
Publication statusPublished - 19 Sep 2015

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