Inflammasomes in the Kidney

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Inflammasomes influence a diverse range of kidney disease, including acute and chronic kidney diseases, and those mediated by innate and adaptive immunity. Both IL-18 and in particular IL-1β are validated therapeutic targets in several kidney diseases. In addition to leukocyte-derived inflammasomes, renal tissue cells express functional inflammasome components. Furthermore, a range of endogenous substances that directly activate inflammasomes also mediate kidney injury. Many of the functional studies have focussed on the NLRP3 inflammasome, and there is also evidence for the involvement of other inflammasomes in some conditions. While, at least in some disease, the mechanistic details of the involvement of the inflammasome remain to be elucidated, therapies focussed on inflammasomes and their products have potential in treating kidney disease in the future.

Original languageEnglish
Title of host publicationInflammasomes
Subtitle of host publicationClinical and Therapeutic Implications
EditorsMario Cordero, Elisabet Alcocer-Gomez
Place of PublicationCham, Switzerland
PublisherSpringer
Chapter8
Pages177-210
Number of pages34
ISBN (Electronic)9783319893907
ISBN (Print)9783319893891
DOIs
Publication statusPublished - 1 Jan 2018

Publication series

NameExperientia Supplementum
Volume108
ISSN (Print)1664-431X
ISSN (Electronic)2504-3692

Keywords

  • Acute kidney injury
  • Diabetic nephropathy
  • Glomerulonephritis
  • Inflammasome
  • Interleukin-1β

Cite this

Hutton, H., Alikhan, M., & Kitching, R. (2018). Inflammasomes in the Kidney. In M. Cordero, & E. Alcocer-Gomez (Eds.), Inflammasomes: Clinical and Therapeutic Implications (pp. 177-210). (Experientia Supplementum; Vol. 108). Cham, Switzerland: Springer. https://doi.org/10.1007/978-3-319-89390-7_8
Hutton, Holly ; Alikhan, Maliha ; Kitching, Richard. / Inflammasomes in the Kidney. Inflammasomes: Clinical and Therapeutic Implications. editor / Mario Cordero ; Elisabet Alcocer-Gomez. Cham, Switzerland : Springer, 2018. pp. 177-210 (Experientia Supplementum).
@inbook{b41de286b1904985b24d41e7538fdb59,
title = "Inflammasomes in the Kidney",
abstract = "Inflammasomes influence a diverse range of kidney disease, including acute and chronic kidney diseases, and those mediated by innate and adaptive immunity. Both IL-18 and in particular IL-1β are validated therapeutic targets in several kidney diseases. In addition to leukocyte-derived inflammasomes, renal tissue cells express functional inflammasome components. Furthermore, a range of endogenous substances that directly activate inflammasomes also mediate kidney injury. Many of the functional studies have focussed on the NLRP3 inflammasome, and there is also evidence for the involvement of other inflammasomes in some conditions. While, at least in some disease, the mechanistic details of the involvement of the inflammasome remain to be elucidated, therapies focussed on inflammasomes and their products have potential in treating kidney disease in the future.",
keywords = "Acute kidney injury, Diabetic nephropathy, Glomerulonephritis, Inflammasome, Interleukin-1β",
author = "Holly Hutton and Maliha Alikhan and Richard Kitching",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/978-3-319-89390-7_8",
language = "English",
isbn = "9783319893891",
series = "Experientia Supplementum",
publisher = "Springer",
pages = "177--210",
editor = "Mario Cordero and Elisabet Alcocer-Gomez",
booktitle = "Inflammasomes",

}

Hutton, H, Alikhan, M & Kitching, R 2018, Inflammasomes in the Kidney. in M Cordero & E Alcocer-Gomez (eds), Inflammasomes: Clinical and Therapeutic Implications. Experientia Supplementum, vol. 108, Springer, Cham, Switzerland, pp. 177-210. https://doi.org/10.1007/978-3-319-89390-7_8

Inflammasomes in the Kidney. / Hutton, Holly; Alikhan, Maliha; Kitching, Richard.

Inflammasomes: Clinical and Therapeutic Implications. ed. / Mario Cordero; Elisabet Alcocer-Gomez. Cham, Switzerland : Springer, 2018. p. 177-210 (Experientia Supplementum; Vol. 108).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

TY - CHAP

T1 - Inflammasomes in the Kidney

AU - Hutton, Holly

AU - Alikhan, Maliha

AU - Kitching, Richard

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Inflammasomes influence a diverse range of kidney disease, including acute and chronic kidney diseases, and those mediated by innate and adaptive immunity. Both IL-18 and in particular IL-1β are validated therapeutic targets in several kidney diseases. In addition to leukocyte-derived inflammasomes, renal tissue cells express functional inflammasome components. Furthermore, a range of endogenous substances that directly activate inflammasomes also mediate kidney injury. Many of the functional studies have focussed on the NLRP3 inflammasome, and there is also evidence for the involvement of other inflammasomes in some conditions. While, at least in some disease, the mechanistic details of the involvement of the inflammasome remain to be elucidated, therapies focussed on inflammasomes and their products have potential in treating kidney disease in the future.

AB - Inflammasomes influence a diverse range of kidney disease, including acute and chronic kidney diseases, and those mediated by innate and adaptive immunity. Both IL-18 and in particular IL-1β are validated therapeutic targets in several kidney diseases. In addition to leukocyte-derived inflammasomes, renal tissue cells express functional inflammasome components. Furthermore, a range of endogenous substances that directly activate inflammasomes also mediate kidney injury. Many of the functional studies have focussed on the NLRP3 inflammasome, and there is also evidence for the involvement of other inflammasomes in some conditions. While, at least in some disease, the mechanistic details of the involvement of the inflammasome remain to be elucidated, therapies focussed on inflammasomes and their products have potential in treating kidney disease in the future.

KW - Acute kidney injury

KW - Diabetic nephropathy

KW - Glomerulonephritis

KW - Inflammasome

KW - Interleukin-1β

UR - http://www.scopus.com/inward/record.url?scp=85066149387&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-89390-7_8

DO - 10.1007/978-3-319-89390-7_8

M3 - Chapter (Book)

SN - 9783319893891

T3 - Experientia Supplementum

SP - 177

EP - 210

BT - Inflammasomes

A2 - Cordero, Mario

A2 - Alcocer-Gomez, Elisabet

PB - Springer

CY - Cham, Switzerland

ER -

Hutton H, Alikhan M, Kitching R. Inflammasomes in the Kidney. In Cordero M, Alcocer-Gomez E, editors, Inflammasomes: Clinical and Therapeutic Implications. Cham, Switzerland: Springer. 2018. p. 177-210. (Experientia Supplementum). https://doi.org/10.1007/978-3-319-89390-7_8