Abstract
Aims: This study aims to describe the incidence of infective complications, including tumour endoprosthesis infection, in a cohort of patients undergoing tumour endoprosthesis surgery in Victoria, Australia.
Methods: This retrospective cohort study was performed over 15 years (January 1996-December 2010).
Results: 121 patients underwent tumour endoprosthesis surgery during the study period. Patients were followed for a median of 34 months (interquartile range [IQR] 17, 80). Overall, 34 patients (28%) experienced infective complications including: bacteraemia in 19 patients (16%) and tumour endoprosthesis infection in 17 (14%). The majority of patients with early and late acute infections (haematogenous) were managed with debridement and retention of the prosthesis in addition to biofilm-active antibiotics. Late chronic infections were predominantly managed by exchange of the prosthesis. The overall success rate of treatment was 71%. The success rate for debridement and retention was 75% compared with 67% for exchange procedures.
Conclusions: There is a significant rate of infective complications following tumour endoprosthesis surgery including 14% of patients experiencing infection involving the tumour endoprosthesis. This study is the first to report on outcomes from debridement and retention of the prosthesis; which had comparable success rates to other treatment modalities.
Original language | English |
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Pages (from-to) | 1087-1094 |
Number of pages | 8 |
Journal | European Journal of Surgical Oncology |
Volume | 40 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2014 |
Externally published | Yes |
Keywords
- Bone and soft tissue tumour
- Epidemiology
- Infection
- Outcome
- Treatment
- Tumour endoprosthesis infection
- Tumour endoprosthesis surgery