Infection-related hospitalization in childhood and adult metabolic outcomes

David P. Burgner, Matthew A. Sabin, Costan G. Magnussen, Michael M H Cheung, Mika Kähönen, Terho Lehtimäki, Nina Hutri-Kähönen, Eero Jokinen, Tomi Laitinen, Leena Taittonen, Päivi Tossavainen, Terence Dwyer, Jorma S A Viikari, Olli T Raitakari, Markus Juonala

Research output: Contribution to journalArticleResearchpeer-review

Abstract

BACKGROUND AND OBJECTIVES: Identifying childhood determinants of adult cardiometabolic disease would facilitate early-life interventions. There are few longitudinal data on the contribution of childhood infections. Therefore, we investigated whether hospitalization with childhood infection is associated with adult anthropometric and metabolic outcomes in a large, wellphenotyped longitudinal cohort. METHODS: A total of 1376 subjects from the Cardiovascular Risk in Young Finns Study, aged 3 to 9 years at baseline (1980), who had lifetime data from birth onward on infection-related hospitalization (IRH) had repeated assessments through childhood and adolescence and at least once in adulthood (age 30-45 years in 2001-2011). Early childhood (<5 years), childhood/adolescence (5-18 years), adult (>18 years), and total lifetime IRHs were related to adiposity, BMI, and metabolic syndrome in adulthood. Analyses were adjusted for childhood and adulthood risk factors and potential confounders. RESULTS: Early-childhood IRH correlated with adverse adult but not childhood metabolic variables: increased BMI (P =.02) and metabolic syndrome (risk ratio: 1.56; 95% confidence interval: 1.03-2.35; P =.03), adjusted for age, gender, birth weight, childhood BMI and other risk factors, and family income. The age at which differences in adult BMI became persistent was related to age of IRH in childhood. The greatest increase in adult BMI occurred in those with >1 childhood IRH. CONCLUSIONS: Childhood IRH was independently associated with adverse adult metabolic variables. This finding suggests that infections and/or their treatment in childhood may contribute to causal pathways leading to adult cardiometabolic diseases.

Original languageEnglish
Pages (from-to)e554-e562
Number of pages9
JournalPediatrics
Volume136
Issue number3
DOIs
Publication statusPublished - 1 Sep 2015

Cite this

Burgner, D. P., Sabin, M. A., Magnussen, C. G., Cheung, M. M. H., Kähönen, M., Lehtimäki, T., ... Juonala, M. (2015). Infection-related hospitalization in childhood and adult metabolic outcomes. Pediatrics, 136(3), e554-e562. https://doi.org/10.1542/peds.2015-0825
Burgner, David P. ; Sabin, Matthew A. ; Magnussen, Costan G. ; Cheung, Michael M H ; Kähönen, Mika ; Lehtimäki, Terho ; Hutri-Kähönen, Nina ; Jokinen, Eero ; Laitinen, Tomi ; Taittonen, Leena ; Tossavainen, Päivi ; Dwyer, Terence ; Viikari, Jorma S A ; Raitakari, Olli T ; Juonala, Markus. / Infection-related hospitalization in childhood and adult metabolic outcomes. In: Pediatrics. 2015 ; Vol. 136, No. 3. pp. e554-e562.
@article{5b3b553e613849d9af9723ac3fc97e34,
title = "Infection-related hospitalization in childhood and adult metabolic outcomes",
abstract = "BACKGROUND AND OBJECTIVES: Identifying childhood determinants of adult cardiometabolic disease would facilitate early-life interventions. There are few longitudinal data on the contribution of childhood infections. Therefore, we investigated whether hospitalization with childhood infection is associated with adult anthropometric and metabolic outcomes in a large, wellphenotyped longitudinal cohort. METHODS: A total of 1376 subjects from the Cardiovascular Risk in Young Finns Study, aged 3 to 9 years at baseline (1980), who had lifetime data from birth onward on infection-related hospitalization (IRH) had repeated assessments through childhood and adolescence and at least once in adulthood (age 30-45 years in 2001-2011). Early childhood (<5 years), childhood/adolescence (5-18 years), adult (>18 years), and total lifetime IRHs were related to adiposity, BMI, and metabolic syndrome in adulthood. Analyses were adjusted for childhood and adulthood risk factors and potential confounders. RESULTS: Early-childhood IRH correlated with adverse adult but not childhood metabolic variables: increased BMI (P =.02) and metabolic syndrome (risk ratio: 1.56; 95{\%} confidence interval: 1.03-2.35; P =.03), adjusted for age, gender, birth weight, childhood BMI and other risk factors, and family income. The age at which differences in adult BMI became persistent was related to age of IRH in childhood. The greatest increase in adult BMI occurred in those with >1 childhood IRH. CONCLUSIONS: Childhood IRH was independently associated with adverse adult metabolic variables. This finding suggests that infections and/or their treatment in childhood may contribute to causal pathways leading to adult cardiometabolic diseases.",
author = "Burgner, {David P.} and Sabin, {Matthew A.} and Magnussen, {Costan G.} and Cheung, {Michael M H} and Mika K{\"a}h{\"o}nen and Terho Lehtim{\"a}ki and Nina Hutri-K{\"a}h{\"o}nen and Eero Jokinen and Tomi Laitinen and Leena Taittonen and P{\"a}ivi Tossavainen and Terence Dwyer and Viikari, {Jorma S A} and Raitakari, {Olli T} and Markus Juonala",
year = "2015",
month = "9",
day = "1",
doi = "10.1542/peds.2015-0825",
language = "English",
volume = "136",
pages = "e554--e562",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "3",

}

Burgner, DP, Sabin, MA, Magnussen, CG, Cheung, MMH, Kähönen, M, Lehtimäki, T, Hutri-Kähönen, N, Jokinen, E, Laitinen, T, Taittonen, L, Tossavainen, P, Dwyer, T, Viikari, JSA, Raitakari, OT & Juonala, M 2015, 'Infection-related hospitalization in childhood and adult metabolic outcomes', Pediatrics, vol. 136, no. 3, pp. e554-e562. https://doi.org/10.1542/peds.2015-0825

Infection-related hospitalization in childhood and adult metabolic outcomes. / Burgner, David P.; Sabin, Matthew A.; Magnussen, Costan G.; Cheung, Michael M H; Kähönen, Mika; Lehtimäki, Terho; Hutri-Kähönen, Nina; Jokinen, Eero; Laitinen, Tomi; Taittonen, Leena; Tossavainen, Päivi; Dwyer, Terence; Viikari, Jorma S A; Raitakari, Olli T; Juonala, Markus.

In: Pediatrics, Vol. 136, No. 3, 01.09.2015, p. e554-e562.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Infection-related hospitalization in childhood and adult metabolic outcomes

AU - Burgner, David P.

AU - Sabin, Matthew A.

AU - Magnussen, Costan G.

AU - Cheung, Michael M H

AU - Kähönen, Mika

AU - Lehtimäki, Terho

AU - Hutri-Kähönen, Nina

AU - Jokinen, Eero

AU - Laitinen, Tomi

AU - Taittonen, Leena

AU - Tossavainen, Päivi

AU - Dwyer, Terence

AU - Viikari, Jorma S A

AU - Raitakari, Olli T

AU - Juonala, Markus

PY - 2015/9/1

Y1 - 2015/9/1

N2 - BACKGROUND AND OBJECTIVES: Identifying childhood determinants of adult cardiometabolic disease would facilitate early-life interventions. There are few longitudinal data on the contribution of childhood infections. Therefore, we investigated whether hospitalization with childhood infection is associated with adult anthropometric and metabolic outcomes in a large, wellphenotyped longitudinal cohort. METHODS: A total of 1376 subjects from the Cardiovascular Risk in Young Finns Study, aged 3 to 9 years at baseline (1980), who had lifetime data from birth onward on infection-related hospitalization (IRH) had repeated assessments through childhood and adolescence and at least once in adulthood (age 30-45 years in 2001-2011). Early childhood (<5 years), childhood/adolescence (5-18 years), adult (>18 years), and total lifetime IRHs were related to adiposity, BMI, and metabolic syndrome in adulthood. Analyses were adjusted for childhood and adulthood risk factors and potential confounders. RESULTS: Early-childhood IRH correlated with adverse adult but not childhood metabolic variables: increased BMI (P =.02) and metabolic syndrome (risk ratio: 1.56; 95% confidence interval: 1.03-2.35; P =.03), adjusted for age, gender, birth weight, childhood BMI and other risk factors, and family income. The age at which differences in adult BMI became persistent was related to age of IRH in childhood. The greatest increase in adult BMI occurred in those with >1 childhood IRH. CONCLUSIONS: Childhood IRH was independently associated with adverse adult metabolic variables. This finding suggests that infections and/or their treatment in childhood may contribute to causal pathways leading to adult cardiometabolic diseases.

AB - BACKGROUND AND OBJECTIVES: Identifying childhood determinants of adult cardiometabolic disease would facilitate early-life interventions. There are few longitudinal data on the contribution of childhood infections. Therefore, we investigated whether hospitalization with childhood infection is associated with adult anthropometric and metabolic outcomes in a large, wellphenotyped longitudinal cohort. METHODS: A total of 1376 subjects from the Cardiovascular Risk in Young Finns Study, aged 3 to 9 years at baseline (1980), who had lifetime data from birth onward on infection-related hospitalization (IRH) had repeated assessments through childhood and adolescence and at least once in adulthood (age 30-45 years in 2001-2011). Early childhood (<5 years), childhood/adolescence (5-18 years), adult (>18 years), and total lifetime IRHs were related to adiposity, BMI, and metabolic syndrome in adulthood. Analyses were adjusted for childhood and adulthood risk factors and potential confounders. RESULTS: Early-childhood IRH correlated with adverse adult but not childhood metabolic variables: increased BMI (P =.02) and metabolic syndrome (risk ratio: 1.56; 95% confidence interval: 1.03-2.35; P =.03), adjusted for age, gender, birth weight, childhood BMI and other risk factors, and family income. The age at which differences in adult BMI became persistent was related to age of IRH in childhood. The greatest increase in adult BMI occurred in those with >1 childhood IRH. CONCLUSIONS: Childhood IRH was independently associated with adverse adult metabolic variables. This finding suggests that infections and/or their treatment in childhood may contribute to causal pathways leading to adult cardiometabolic diseases.

UR - http://www.scopus.com/inward/record.url?scp=84940855704&partnerID=8YFLogxK

U2 - 10.1542/peds.2015-0825

DO - 10.1542/peds.2015-0825

M3 - Article

VL - 136

SP - e554-e562

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 3

ER -

Burgner DP, Sabin MA, Magnussen CG, Cheung MMH, Kähönen M, Lehtimäki T et al. Infection-related hospitalization in childhood and adult metabolic outcomes. Pediatrics. 2015 Sep 1;136(3):e554-e562. https://doi.org/10.1542/peds.2015-0825