Induction of CD8+ T cells using heterologous prime-boost immunisation strategies

Jörg Schneider, Sarah C. Gilbert, Carolyn M. Hannan, Pilar Dégano, Eric Prieur, Eric G. Sheu, Magdalena Plebanski, Adrian V S Hill

Research output: Contribution to journalReview ArticleResearchpeer-review

171 Citations (Scopus)


One of the current challenges in vaccine design is the development of antigen delivery systems or vaccination strategies that induce high protective levels of CD8+ T cells. These cells are crucial for protection against certain tumours and intracellular pathogens such as the liver-stage parasite of malaria. A liver-stage malaria vaccine should therefore include CD8+ T-cell-inducing components. This review provides an overview of prime-boost immunisation strategies that result in protective CD8+ T-cell responses against malaria with an emphasis on work from our laboratory. Possible mechanisms explaining why heterologous prime-boost strategies, in particular boosting with replication-impaired recombinant poxviruses, are so effective are discussed.

Original languageEnglish
Pages (from-to)29-38
Number of pages10
JournalImmunological Reviews
Publication statusPublished - 1999
Externally publishedYes

Cite this