Induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein

Anthony Slavin, Christine Ewing, Junliang Liu, Motoki Ichikawa, John Slavin, Claude C.A. Bernard

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123 Citations (Scopus)

Abstract

Myelin oligodendrocyte glycoprotein (MOG) is postulated to be a target autoantigen in multiple sclerosis (MS). Here we investigated the encephalitogenicity of an immunodominant epitope of MOG, peptide 35-55, in various strains of mice. An MS-like disease was induced in NOD/Lt mice H-2(g7) and C57BL/6 mice (W-2b) by a single injection of MOG35-55 in CFA. The disease followed a relapsing-remitting course in NOD/Lt mice, ,whereas C57BL/6 mice developed a chronic paralytic disease. Histologically, the disease in both strains was characterized by cellular infiltration and multifocal demyelination in the CNS. Significant DTH type reactions to MOG35-55 were only seen in MOG-susceptible animals, with the NOD/Lt mice showing the strongest responses. Susceptible mice also showed specific antibody responses to MOG35-55 but not to a panel of other MOG peptides. These results provide further evidence for the role of MOG as a highly autoantigenic molecule capable of inducing severe demyelinating disease.

Original languageEnglish
Pages (from-to)109-120
Number of pages12
JournalAutoimmunity
Volume28
Issue number2
DOIs
Publication statusPublished - 1998
Externally publishedYes

Keywords

  • Antibody
  • Delayed hypersensitivity reaction
  • Demyelination
  • Encephalitogenic peptide
  • Multiple sclerosis
  • Myelin oligodendrocyte glycoprotein

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