Abstract
Myelin oligodendrocyte glycoprotein (MOG) is postulated to be a target autoantigen in multiple sclerosis (MS). Here we investigated the encephalitogenicity of an immunodominant epitope of MOG, peptide 35-55, in various strains of mice. An MS-like disease was induced in NOD/Lt mice H-2(g7) and C57BL/6 mice (W-2b) by a single injection of MOG35-55 in CFA. The disease followed a relapsing-remitting course in NOD/Lt mice, ,whereas C57BL/6 mice developed a chronic paralytic disease. Histologically, the disease in both strains was characterized by cellular infiltration and multifocal demyelination in the CNS. Significant DTH type reactions to MOG35-55 were only seen in MOG-susceptible animals, with the NOD/Lt mice showing the strongest responses. Susceptible mice also showed specific antibody responses to MOG35-55 but not to a panel of other MOG peptides. These results provide further evidence for the role of MOG as a highly autoantigenic molecule capable of inducing severe demyelinating disease.
Original language | English |
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Pages (from-to) | 109-120 |
Number of pages | 12 |
Journal | Autoimmunity |
Volume | 28 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1998 |
Externally published | Yes |
Keywords
- Antibody
- Delayed hypersensitivity reaction
- Demyelination
- Encephalitogenic peptide
- Multiple sclerosis
- Myelin oligodendrocyte glycoprotein