Induction monotherapy with sirolimus has selected beneficial effects on glomerular and tubulointersititial injury in nephrotoxic serum nephritis

Lena Succar, Julia E Lai-Kwon, David J Nikolic-Paterson, Gopala K Rangan

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Abstract

BACKGROUND: The study aimed to test the hypothesis that therapeutic treatment with a mammalian target of rapamycin complex 1 inhibitor reduces renal cell proliferation and attenuates glomerular and tubulointerstitial injury in the early phase of nephrotoxic serum nephritis (NSN) in rats. METHODS: Male Wistar-Kyoto rats received a single tail-vein injection of sheep anti-rat glomerular basement membrane serum (day 0) and were treated with vehicle or sirolimus (0.25 mg/kg/day by subcutaneous injection) from day 1 until day 14. RESULTS: Treatment with sirolimus attenuated kidney enlargement by 41 (P
Original languageEnglish
Pages (from-to)303 - 313
Number of pages11
JournalInternational Journal of Nephrology and Renovascular Disease
Volume7
DOIs
Publication statusPublished - 2014

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