Inducing stroke in aged, hypertensive, diabetic rats

Sarah S.J. Rewell; John A. Fernandez; Susan F. Cox; Neil J. Spratt; Lisa Hogan; Elena Aleksoska; Leena Van Raay; Gabriel T. Liberatore; Peter E. Batchelor; David W. Howells

doi:10.1038/jcbfm.2009.273

Inducing stroke in aged, hypertensive, diabetic rats

Sarah S.J. Rewell, John A. Fernandez, Susan F. Cox, Neil J. Spratt, Lisa Hogan, Elena Aleksoska, Leena Van Raay, Gabriel T. Liberatore, Peter E. Batchelor, David W. Howells

Research output: Contribution to journal › Article › Research › peer-review

35 Citations (Scopus)

Abstract

Animal models of ischemic stroke often neglect comorbidities common in patients. This study shows the feasibility of inducing stroke by 2h of thread occlusion of the middle cerebral artery in aged (56 week old) spontaneously hypertensive rats (SHRs) with both acute (2 weeks) and chronic (36 weeks) diabetes. After modifying the streptozotocin dosing regimen to ensure that old SHRs survived the induction of diabetes, few died after induction of stroke. Induction of stroke is feasible in rats with multiple comorbidities. Inclusion of such comorbid animals may improve translation from the research laboratory to the clinic.

Original language	English
Pages (from-to)	729-733
Number of pages	5
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	30
Issue number	4
DOIs	https://doi.org/10.1038/jcbfm.2009.273
Publication status	Published - 1 Apr 2010
Externally published	Yes

Keywords

Aging
Diabetes mellitus
Experimental
Hypertension
Rats
SHR
Stroke

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/jcbfm.2009.273

Cite this

@article{a926b9bc807b4df89a079ded9d15db00,

title = "Inducing stroke in aged, hypertensive, diabetic rats",

abstract = "Animal models of ischemic stroke often neglect comorbidities common in patients. This study shows the feasibility of inducing stroke by 2h of thread occlusion of the middle cerebral artery in aged (56 week old) spontaneously hypertensive rats (SHRs) with both acute (2 weeks) and chronic (36 weeks) diabetes. After modifying the streptozotocin dosing regimen to ensure that old SHRs survived the induction of diabetes, few died after induction of stroke. Induction of stroke is feasible in rats with multiple comorbidities. Inclusion of such comorbid animals may improve translation from the research laboratory to the clinic.",

keywords = "Aging, Diabetes mellitus, Experimental, Hypertension, Rats, SHR, Stroke",

author = "Rewell, {Sarah S.J.} and Fernandez, {John A.} and Cox, {Susan F.} and Spratt, {Neil J.} and Lisa Hogan and Elena Aleksoska and {Van Raay}, Leena and Liberatore, {Gabriel T.} and Batchelor, {Peter E.} and Howells, {David W.}",

year = "2010",

month = apr,

day = "1",

doi = "10.1038/jcbfm.2009.273",

language = "English",

volume = "30",

pages = "729--733",

journal = "Journal of Cerebral Blood Flow and Metabolism",

issn = "0271-678X",

publisher = "SAGE Publications Ltd",

number = "4",

}

TY - JOUR

T1 - Inducing stroke in aged, hypertensive, diabetic rats

AU - Rewell, Sarah S.J.

AU - Fernandez, John A.

AU - Cox, Susan F.

AU - Spratt, Neil J.

AU - Hogan, Lisa

AU - Aleksoska, Elena

AU - Van Raay, Leena

AU - Liberatore, Gabriel T.

AU - Batchelor, Peter E.

AU - Howells, David W.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Animal models of ischemic stroke often neglect comorbidities common in patients. This study shows the feasibility of inducing stroke by 2h of thread occlusion of the middle cerebral artery in aged (56 week old) spontaneously hypertensive rats (SHRs) with both acute (2 weeks) and chronic (36 weeks) diabetes. After modifying the streptozotocin dosing regimen to ensure that old SHRs survived the induction of diabetes, few died after induction of stroke. Induction of stroke is feasible in rats with multiple comorbidities. Inclusion of such comorbid animals may improve translation from the research laboratory to the clinic.

AB - Animal models of ischemic stroke often neglect comorbidities common in patients. This study shows the feasibility of inducing stroke by 2h of thread occlusion of the middle cerebral artery in aged (56 week old) spontaneously hypertensive rats (SHRs) with both acute (2 weeks) and chronic (36 weeks) diabetes. After modifying the streptozotocin dosing regimen to ensure that old SHRs survived the induction of diabetes, few died after induction of stroke. Induction of stroke is feasible in rats with multiple comorbidities. Inclusion of such comorbid animals may improve translation from the research laboratory to the clinic.

KW - Aging

KW - Diabetes mellitus

KW - Experimental

KW - Hypertension

KW - Rats

KW - SHR

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=77950516607&partnerID=8YFLogxK

U2 - 10.1038/jcbfm.2009.273

DO - 10.1038/jcbfm.2009.273

M3 - Article

C2 - 20068574

AN - SCOPUS:77950516607

SN - 0271-678X

VL - 30

SP - 729

EP - 733

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

IS - 4

ER -

Inducing stroke in aged, hypertensive, diabetic rats

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Cite this