Indomethacin has been the mainstay for medical closure of patent ductus arteriosus. With its discontinuation, many units shifted to the use ibuprofen. We compared the therapeutic efficacy (successful closure, a priori defined as complete closure or >50 reduction in size) and the impact of the two drugs on neonatal morbidities.
Malikiwi, A., Roufaeil, C., Tan, K. H. H., & Sehgal, A. (2015). Indomethacin vs ibuprofen: comparison of efficacy in the setting of conservative therapeutic approach. European Journal of Pediatrics, 174(5), 615 - 620. https://doi.org/10.1007/s00431-014-2441-0