Individuals with depression display abnormal modulation of neural oscillatory activity during working memory encoding and maintenance

O.W. Murphy; Kate Hoy; D. Wong; Neil Bailey; Paul B. Fitzgerald; Rebecca Segrave

doi:10.1016/j.biopsycho.2019.107766

Individuals with depression display abnormal modulation of neural oscillatory activity during working memory encoding and maintenance

O.W. Murphy, Kate Hoy, D. Wong, Neil Bailey, Paul B. Fitzgerald, Rebecca Segrave

Research output: Contribution to journal › Article › Research › peer-review

25 Citations (Scopus)

Abstract

Purpose
To investigate neural oscillatory activity supporting working memory (WM) processing in depressed individuals and healthy controls.

Methods
Forty-six participants with Major Depressive Disorder (MDD) and 41 healthy controls balanced on age, gender, and WM ability completed a Sternberg verbal WM task with concurrent electroencephalography recording. Oscillatory activity was calculated for upper alpha, theta, and gamma frequency bands during WM encoding and maintenance.

Results
WM performance did not differ between groups. When compared to healthy controls, depressed individuals displayed reduced frontal-midline theta power and increased occipital upper alpha power during WM encoding, and reductions in frontal-midline theta power and occipital gamma and upper alpha power during WM maintenance. Higher depression severity was associated with greater reductions upper alpha and gamma power during WM maintenance.

Conclusions
Depressed individuals displayed prominent alterations in oscillatory activity during WM encoding and maintenance, indicating that the neural processes which support WM processing are altered in MDD even when no cognitive impairments are observed.

Original language	English
Article number	107766
Number of pages	12
Journal	Biological Psychology
Volume	148
DOIs	https://doi.org/10.1016/j.biopsycho.2019.107766
Publication status	Published - Nov 2019

Keywords

Alpha
Cognitive
Depression
EEG
Gamma
Oscillations
Sternberg task
Theta
Working memory

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10.1016/j.biopsycho.2019.107766

Cite this

@article{7764e3195a7f48519acf77b5c22dc5c7,

title = "Individuals with depression display abnormal modulation of neural oscillatory activity during working memory encoding and maintenance",

abstract = "PurposeTo investigate neural oscillatory activity supporting working memory (WM) processing in depressed individuals and healthy controls.MethodsForty-six participants with Major Depressive Disorder (MDD) and 41 healthy controls balanced on age, gender, and WM ability completed a Sternberg verbal WM task with concurrent electroencephalography recording. Oscillatory activity was calculated for upper alpha, theta, and gamma frequency bands during WM encoding and maintenance.ResultsWM performance did not differ between groups. When compared to healthy controls, depressed individuals displayed reduced frontal-midline theta power and increased occipital upper alpha power during WM encoding, and reductions in frontal-midline theta power and occipital gamma and upper alpha power during WM maintenance. Higher depression severity was associated with greater reductions upper alpha and gamma power during WM maintenance.ConclusionsDepressed individuals displayed prominent alterations in oscillatory activity during WM encoding and maintenance, indicating that the neural processes which support WM processing are altered in MDD even when no cognitive impairments are observed.",

keywords = "Alpha, Cognitive, Depression, EEG, Gamma, Oscillations, Sternberg task, Theta, Working memory",

author = "O.W. Murphy and Kate Hoy and D. Wong and Neil Bailey and Fitzgerald, {Paul B.} and Rebecca Segrave",

year = "2019",

month = nov,

doi = "10.1016/j.biopsycho.2019.107766",

language = "English",

volume = "148",

journal = "Biological Psychology",

issn = "0301-0511",

publisher = "Elsevier BV",

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TY - JOUR

T1 - Individuals with depression display abnormal modulation of neural oscillatory activity during working memory encoding and maintenance

AU - Murphy, O.W.

AU - Hoy, Kate

AU - Wong, D.

AU - Bailey, Neil

AU - Fitzgerald, Paul B.

AU - Segrave, Rebecca

PY - 2019/11

Y1 - 2019/11

N2 - PurposeTo investigate neural oscillatory activity supporting working memory (WM) processing in depressed individuals and healthy controls.MethodsForty-six participants with Major Depressive Disorder (MDD) and 41 healthy controls balanced on age, gender, and WM ability completed a Sternberg verbal WM task with concurrent electroencephalography recording. Oscillatory activity was calculated for upper alpha, theta, and gamma frequency bands during WM encoding and maintenance.ResultsWM performance did not differ between groups. When compared to healthy controls, depressed individuals displayed reduced frontal-midline theta power and increased occipital upper alpha power during WM encoding, and reductions in frontal-midline theta power and occipital gamma and upper alpha power during WM maintenance. Higher depression severity was associated with greater reductions upper alpha and gamma power during WM maintenance.ConclusionsDepressed individuals displayed prominent alterations in oscillatory activity during WM encoding and maintenance, indicating that the neural processes which support WM processing are altered in MDD even when no cognitive impairments are observed.

AB - PurposeTo investigate neural oscillatory activity supporting working memory (WM) processing in depressed individuals and healthy controls.MethodsForty-six participants with Major Depressive Disorder (MDD) and 41 healthy controls balanced on age, gender, and WM ability completed a Sternberg verbal WM task with concurrent electroencephalography recording. Oscillatory activity was calculated for upper alpha, theta, and gamma frequency bands during WM encoding and maintenance.ResultsWM performance did not differ between groups. When compared to healthy controls, depressed individuals displayed reduced frontal-midline theta power and increased occipital upper alpha power during WM encoding, and reductions in frontal-midline theta power and occipital gamma and upper alpha power during WM maintenance. Higher depression severity was associated with greater reductions upper alpha and gamma power during WM maintenance.ConclusionsDepressed individuals displayed prominent alterations in oscillatory activity during WM encoding and maintenance, indicating that the neural processes which support WM processing are altered in MDD even when no cognitive impairments are observed.

KW - Alpha

KW - Cognitive

KW - Depression

KW - EEG

KW - Gamma

KW - Oscillations

KW - Sternberg task

KW - Theta

KW - Working memory

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AN - SCOPUS:85072310423

SN - 0301-0511

VL - 148

JO - Biological Psychology

JF - Biological Psychology

M1 - 107766

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Individuals with depression display abnormal modulation of neural oscillatory activity during working memory encoding and maintenance

Abstract

Keywords

Access to Document

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Deep brain stimulation for treatment resistant major depression: Neural correlates and neuropsychological outcomes

Biomedical Imaging (MBI)

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Individuals with depression display abnormal modulation of neural oscillatory activity during working memory encoding and maintenance

Abstract

Keywords

Access to Document

Other files and links

Projects

Deep brain stimulation for treatment resistant major depression: Neural correlates and neuropsychological outcomes

Equipment

Biomedical Imaging (MBI)

Cite this