Individually-tailored multifactorial intervention to reduce falls in the Malaysian Falls Assessment and Intervention Trial (MyFAIT): A randomized controlled trial

Pey June Tan, Ee Ming Khoo, Karuthan Chinna, Nor I.zzati Saedon, Mohd Idzwan Zakaria, Ahmad Zulkarnain Ahmad Zahedi, Norlina Ramli, Nurliza Khalidin, Mazlina Mazlan, Kok Han Chee, Imran Zainal Abidin, Nemala Nalathamby, Sumaiyah Mat, Mohamad Hasif Jaafar, Hui Min Khor, Norfazilah Mohamad Khannas, Lokman Abdul Majid, Kit Mun Tan, Ai Vyrn Chin, Shahrul Bahyah KamaruzzamanPhilip Poi, Karen Morgan, Keith D. Hill, Lynette MacKenzie, Maw Pin Tan

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14 Citations (Scopus)


Objective To determine the effectiveness of an individually-tailored multifactorial intervention in reducing falls among at risk older adult fallers in a multi-ethnic, middle-income nation in South-East Asia. Design Pragmatic, randomized-controlled trial. Setting Emergency room, medical outpatient and primary care clinic in a teaching hospital in Kuala Lumpur, Malaysia. Participants Individuals aged 65 years and above with two or more falls or one injurious fall in the past 12 months. Intervention Individually-tailored interventions, included a modified Otago exercise programme, HOMEFAST home hazards modification, visual intervention, cardiovascular intervention, medication review and falls education, was compared against a control group involving conventional treatment. Primary and secondary outcome measures The primary outcome was any fall recurrence at 12-month follow-up. Secondary outcomes were rate of fall and time to first fall. Results Two hundred and sixty-eight participants (mean age 75.3 ±7.2 SD years, 67% women) were randomized to multifactorial intervention (n = 134) or convention treatment (n = 134). All participants in the intervention group received medication review and falls education, 92 (68%) were prescribed Otago exercises, 86 (64%) visual intervention, 64 (47%) home hazards modification and 51 (38%) cardiovascular intervention. Fall recurrence did not differ between intervention and control groups at 12-months [Risk Ratio, RR = 1.037 (95% CI 0.613–1.753)]. Rate of fall [RR = 1.155 (95% CI 0.846–1.576], time to first fall [Hazard Ratio, HR = 0.948 (95% CI 0.782–1.522)] and mortality rate [RR = 0.896 (95% CI 0.335–2.400)] did not differ between groups. Conclusion Individually-tailored multifactorial intervention was ineffective as a strategy to reduce falls. Future research efforts are now required to develop culturally-appropriate and affordable methods of addressing this increasingly prominent public health issue in middle-income nations.

Original languageEnglish
Article numbere0199219
Number of pages16
JournalPLoS ONE
Issue number8
Publication statusPublished - 3 Aug 2018
Externally publishedYes

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