Indirect measurement of average alveolar dimension using dynamic phase-contrast imaging

Mercedes Martinson, Rob A Lewis, Andreas Fouras, Melissa Li-Lian Siew, Megan Jane Wallace, Stuart Brian Hooper, Paul Sheppard Babyn

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review


For some lung diseases, assessment of alveolar dimension could add critical information to inform patient care and disease progression. However, current clinical imaging techniques, such as computed tomography, lack the resolution required to measure these small structures in patients. While the gold standard imaging modality for measuring alveoli is micro-CT, this technique is not possible in clinical use due to the size of the patients and the radiation dose. An alternative imaging modality is phase-based contrast imaging, which would deliver a lower dose to patients and increase the size limit. Phase contrast X-ray imaging has previously been combined with particle image velocimetry (PIV) to measure lung motion, another indicator of lung disease. Thus it was hypothesized that average alveolar size could also be measured indirectly using PIV. In the work reported here, we show that average alveolar size shows a high correlation to the mathematical divergence of the velocity vector field that results from the speckle pattern produced by phase imaging of mouse lungs. This correlation is linear with p
Original languageEnglish
Title of host publicationIFMBE Proceedings
EditorsDavid A Jaffray
Place of PublicationSwitzerland
Pages166 - 168
Number of pages3
ISBN (Print)9783319193878
Publication statusPublished - 2015
EventWorld Congress on Medical Physics and Biomedical Engineering 2015 - Toronto, Canada
Duration: 7 Jun 201512 Jun 2015


ConferenceWorld Congress on Medical Physics and Biomedical Engineering 2015
Abbreviated titleWC 2015

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