IncX3 plasmid harboring a non-Tn4401 genetic element (NTEKPC) in a hospital-associated clone of KPC-2-producing Klebsiella pneumoniae ST340/CG258

Louise T. Cerdeira; Marcos P.V. Cunha; Gabriela R. Francisco; Maria Fernanda C. Bueno; Bruna F. Araujo; Rosineide M. Ribas; Paulo P. Gontijo-Filho; Terezinha Knöbl; Doroti de Oliveira Garcia; Nilton Lincopan

doi:10.1016/j.diagmicrobio.2017.06.022

IncX3 plasmid harboring a non-Tn4401 genetic element (NTE_KPC) in a hospital-associated clone of KPC-2-producing Klebsiella pneumoniae ST340/CG258

Louise T. Cerdeira, Marcos P.V. Cunha, Gabriela R. Francisco, Maria Fernanda C. Bueno, Bruna F. Araujo, Rosineide M. Ribas, Paulo P. Gontijo-Filho, Terezinha Knöbl, Doroti de Oliveira Garcia, Nilton Lincopan

Research output: Contribution to journal › Article › Research › peer-review

22 Citations (Scopus)

Abstract

IncX-type plasmids have achieved clinical significance for their contribution in the dissemination of genes confering resistance to carbapenems (most bla_KPC- and bla_NDM-type genes) and polymyxins (mcr-type genes), both antibiotics considered last resort for multidrug-resistant Gram-negative infections. In this study, we report the identification and complete sequence analysis of an IncX3 plasmid (designated pKP1194a) carrying a non-Tn4401 genetic element (NTE_KPC) of tnpR-tnpA (partial)-bla_KPC-2-ΔISKpn6/traN, originating from a hospital-associated lineage of K. pneumoniae belonging to the ST340/CG258, with epidemiological link to Brazil.

Original language	English
Pages (from-to)	164-167
Number of pages	4
Journal	Diagnostic Microbiology and Infectious Disease
Volume	89
Issue number	2
DOIs	https://doi.org/10.1016/j.diagmicrobio.2017.06.022
Publication status	Published - Oct 2017
Externally published	Yes

Keywords

Brazil
Carbapenemase
CC258
IncX3
Klebsiella pneumoniae
KPC-2

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.diagmicrobio.2017.06.022

Cite this

Cerdeira, L. T., Cunha, M. P. V., Francisco, G. R., Bueno, M. F. C., Araujo, B. F., Ribas, R. M., Gontijo-Filho, P. P., Knöbl, T., de Oliveira Garcia, D., & Lincopan, N. (2017). IncX3 plasmid harboring a non-Tn4401 genetic element (NTE_KPC) in a hospital-associated clone of KPC-2-producing Klebsiella pneumoniae ST340/CG258. Diagnostic Microbiology and Infectious Disease, 89(2), 164-167. https://doi.org/10.1016/j.diagmicrobio.2017.06.022

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title = "IncX3 plasmid harboring a non-Tn4401 genetic element (NTEKPC) in a hospital-associated clone of KPC-2-producing Klebsiella pneumoniae ST340/CG258",

abstract = "IncX-type plasmids have achieved clinical significance for their contribution in the dissemination of genes confering resistance to carbapenems (most blaKPC- and blaNDM-type genes) and polymyxins (mcr-type genes), both antibiotics considered last resort for multidrug-resistant Gram-negative infections. In this study, we report the identification and complete sequence analysis of an IncX3 plasmid (designated pKP1194a) carrying a non-Tn4401 genetic element (NTEKPC) of tnpR-tnpA (partial)-blaKPC-2-ΔISKpn6/traN, originating from a hospital-associated lineage of K. pneumoniae belonging to the ST340/CG258, with epidemiological link to Brazil.",

keywords = "Brazil, Carbapenemase, CC258, IncX3, Klebsiella pneumoniae, KPC-2",

author = "Cerdeira, {Louise T.} and Cunha, {Marcos P.V.} and Francisco, {Gabriela R.} and Bueno, {Maria Fernanda C.} and Araujo, {Bruna F.} and Ribas, {Rosineide M.} and Gontijo-Filho, {Paulo P.} and Terezinha Kn{\"o}bl and {de Oliveira Garcia}, Doroti and Nilton Lincopan",

year = "2017",

month = oct,

doi = "10.1016/j.diagmicrobio.2017.06.022",

language = "English",

volume = "89",

pages = "164--167",

journal = "Diagnostic Microbiology and Infectious Disease",

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Cerdeira, LT, Cunha, MPV, Francisco, GR, Bueno, MFC, Araujo, BF, Ribas, RM, Gontijo-Filho, PP, Knöbl, T, de Oliveira Garcia, D & Lincopan, N 2017, 'IncX3 plasmid harboring a non-Tn4401 genetic element (NTE_KPC) in a hospital-associated clone of KPC-2-producing Klebsiella pneumoniae ST340/CG258', Diagnostic Microbiology and Infectious Disease, vol. 89, no. 2, pp. 164-167. https://doi.org/10.1016/j.diagmicrobio.2017.06.022

IncX3 plasmid harboring a non-Tn4401 genetic element (NTE_KPC) in a hospital-associated clone of KPC-2-producing Klebsiella pneumoniae ST340/CG258. / Cerdeira, Louise T.; Cunha, Marcos P.V.; Francisco, Gabriela R. et al.
In: Diagnostic Microbiology and Infectious Disease, Vol. 89, No. 2, 10.2017, p. 164-167.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Cerdeira, Louise T.

AU - Cunha, Marcos P.V.

AU - Francisco, Gabriela R.

AU - Bueno, Maria Fernanda C.

AU - Araujo, Bruna F.

AU - Ribas, Rosineide M.

AU - Gontijo-Filho, Paulo P.

AU - Knöbl, Terezinha

AU - de Oliveira Garcia, Doroti

AU - Lincopan, Nilton

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AB - IncX-type plasmids have achieved clinical significance for their contribution in the dissemination of genes confering resistance to carbapenems (most blaKPC- and blaNDM-type genes) and polymyxins (mcr-type genes), both antibiotics considered last resort for multidrug-resistant Gram-negative infections. In this study, we report the identification and complete sequence analysis of an IncX3 plasmid (designated pKP1194a) carrying a non-Tn4401 genetic element (NTEKPC) of tnpR-tnpA (partial)-blaKPC-2-ΔISKpn6/traN, originating from a hospital-associated lineage of K. pneumoniae belonging to the ST340/CG258, with epidemiological link to Brazil.

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