IncX3 plasmid harboring a non-Tn4401 genetic element (NTEKPC) in a hospital-associated clone of KPC-2-producing Klebsiella pneumoniae ST340/CG258

Louise T. Cerdeira, Marcos P.V. Cunha, Gabriela R. Francisco, Maria Fernanda C. Bueno, Bruna F. Araujo, Rosineide M. Ribas, Paulo P. Gontijo-Filho, Terezinha Knöbl, Doroti de Oliveira Garcia, Nilton Lincopan

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Abstract

IncX-type plasmids have achieved clinical significance for their contribution in the dissemination of genes confering resistance to carbapenems (most blaKPC- and blaNDM-type genes) and polymyxins (mcr-type genes), both antibiotics considered last resort for multidrug-resistant Gram-negative infections. In this study, we report the identification and complete sequence analysis of an IncX3 plasmid (designated pKP1194a) carrying a non-Tn4401 genetic element (NTEKPC) of tnpR-tnpA (partial)-blaKPC-2-ΔISKpn6/traN, originating from a hospital-associated lineage of K. pneumoniae belonging to the ST340/CG258, with epidemiological link to Brazil.

Original languageEnglish
Pages (from-to)164-167
Number of pages4
JournalDiagnostic Microbiology and Infectious Disease
Volume89
Issue number2
DOIs
Publication statusPublished - Oct 2017
Externally publishedYes

Keywords

  • Brazil
  • Carbapenemase
  • CC258
  • IncX3
  • Klebsiella pneumoniae
  • KPC-2

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