TY - JOUR
T1 - Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs
AU - Cuine, Jean
AU - Charman, William Neil
AU - Pouton, Colin William
AU - Edwards, Glenn A
AU - Porter, Christopher John
PY - 2007
Y1 - 2007
N2 - To investigate the impact of a change in the proportions of lipid, surfactant and co-solvent on the solubilisation capacity of self-emulsifying formulations of danazol during in vitro dispersion and digestion studies and correlation with in vivo bioavailability in beagle dogs
AB - To investigate the impact of a change in the proportions of lipid, surfactant and co-solvent on the solubilisation capacity of self-emulsifying formulations of danazol during in vitro dispersion and digestion studies and correlation with in vivo bioavailability in beagle dogs
M3 - Article
SN - 0724-8741
VL - 24
SP - 748
EP - 757
JO - Pharmaceutical Research
JF - Pharmaceutical Research
IS - 4
ER -