Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs

Research output: Contribution to journalArticleResearchpeer-review

125 Citations (Scopus)

Abstract

To investigate the impact of a change in the proportions of lipid, surfactant and co-solvent on the solubilisation capacity of self-emulsifying formulations of danazol during in vitro dispersion and digestion studies and correlation with in vivo bioavailability in beagle dogs
Original languageEnglish
Pages (from-to)748 - 757
Number of pages10
JournalPharmaceutical Research
Volume24
Issue number4
Publication statusPublished - 2007

Cite this