Abstract
To investigate the impact of a change in the proportions of lipid, surfactant and co-solvent on the solubilisation capacity of self-emulsifying formulations of danazol during in vitro dispersion and digestion studies and correlation with in vivo bioavailability in beagle dogs
| Original language | English |
|---|---|
| Pages (from-to) | 748 - 757 |
| Number of pages | 10 |
| Journal | Pharmaceutical Research |
| Volume | 24 |
| Issue number | 4 |
| Publication status | Published - 2007 |
Cite this
Cuine, J., Charman, W. N., Pouton, C. W., Edwards, G. A., & Porter, C. J. (2007). Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs. Pharmaceutical Research, 24(4), 748 - 757.