Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs

Jean Cuine; William Neil Charman; Colin William Pouton; Glenn A Edwards; Christopher John Porter

Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs

Jean Cuine, William Neil Charman, Colin William Pouton, Glenn A Edwards, Christopher John Porter

Research output: Contribution to journal › Article › Research › peer-review

Abstract

To investigate the impact of a change in the proportions of lipid, surfactant and co-solvent on the solubilisation capacity of self-emulsifying formulations of danazol during in vitro dispersion and digestion studies and correlation with in vivo bioavailability in beagle dogs

Original language	English
Pages (from-to)	748 - 757
Number of pages	10
Journal	Pharmaceutical Research
Volume	24
Issue number	4
Publication status	Published - 2007

Cite this

@article{fbe58596fa7b43cca1c7a9dcd4d37b8d,

title = "Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs",

abstract = "To investigate the impact of a change in the proportions of lipid, surfactant and co-solvent on the solubilisation capacity of self-emulsifying formulations of danazol during in vitro dispersion and digestion studies and correlation with in vivo bioavailability in beagle dogs",

author = "Jean Cuine and Charman, {William Neil} and Pouton, {Colin William} and Edwards, {Glenn A} and Porter, {Christopher John}",

year = "2007",

language = "English",

volume = "24",

pages = "748 -- 757",

journal = "Pharmaceutical Research",

issn = "0724-8741",

publisher = "Springer",

number = "4",

}

Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs. / Cuine, Jean; Charman, William Neil; Pouton, Colin William et al.
In: Pharmaceutical Research, Vol. 24, No. 4, 2007, p. 748 - 757.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs

AU - Cuine, Jean

AU - Charman, William Neil

AU - Pouton, Colin William

AU - Edwards, Glenn A

AU - Porter, Christopher John

PY - 2007

Y1 - 2007

N2 - To investigate the impact of a change in the proportions of lipid, surfactant and co-solvent on the solubilisation capacity of self-emulsifying formulations of danazol during in vitro dispersion and digestion studies and correlation with in vivo bioavailability in beagle dogs

AB - To investigate the impact of a change in the proportions of lipid, surfactant and co-solvent on the solubilisation capacity of self-emulsifying formulations of danazol during in vitro dispersion and digestion studies and correlation with in vivo bioavailability in beagle dogs

M3 - Article

SN - 0724-8741

VL - 24

SP - 748

EP - 757

JO - Pharmaceutical Research

JF - Pharmaceutical Research

IS - 4

ER -