Increasing pharmacological knowledge about human neurological and psychiatric disorders through functional neuroimaging and its application in drug discovery

Pradeep Jonathan Nathan, Kinh Luan Phan, Catherine J Harmer, Mitul A Mehta, Edward Bullmore

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Abstract

Functional imaging methods such as fMRI have been widely used to gain greater understanding of brain circuitry abnormalities in CNS disorders and their underlying neurochemical basis. Findings suggest that: (1) drugs with known clinical efficacy have consistent effects on disease relevant brain circuitry, (2) brain activation changes at baseline or early drug effects on brain activity can predict long-term efficacy; and (3) fMRI together with pharmacological challenges could serve as experimental models of disease phenotypes and be used for screening novel drugs. Together, these observations suggest that drug related modulation of disease relevant brain circuitry may serve as a promising biomarker/method for use in drug discovery to demonstrate target engagement, differential efficacy, dose-response relationships, and prediction of clinically relevant changes
Original languageEnglish
Pages (from-to)54 - 61
Number of pages8
JournalCurrent Opinion in Pharmacology
Volume14
Issue number1
DOIs
Publication statusPublished - 2014

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