Increasing macrolide and fluoroquinolone resistance in Mycoplasma genitalium

Gerald L. Murray; Catriona S. Bradshaw; Melanie Bissessor; Jennifer A Danielewski; Suzanne M. Garland; Jørgen S. Jensen; Christopher K. Fairley; Sepehr N. Tabrizi

doi:10.3201/eid2305.161745

Increasing macrolide and fluoroquinolone resistance in Mycoplasma genitalium

Gerald L. Murray, Catriona S. Bradshaw, Melanie Bissessor, Jennifer A Danielewski, Suzanne M. Garland, Jørgen S. Jensen, Christopher K. Fairley, Sepehr N. Tabrizi

Research output: Contribution to journal › Article › Research › peer-review

123 Citations (Scopus)

Abstract

Escalating resistance to azithromycin and moxifloxacin is being reported for Mycoplasma genitalium in the Asia-Pacific region. Analyzing 140 infections, we found pretreatment fluoroquinolone-resistance mutations in parC (13.6%) and gyrA (5%). ParC S83 changes were associated with moxifloxacin failure. Macrolide/fluoroquinolone-resistance mutations were in 8.6% of specimens, for which recommended therapies would be ineffective.

Original language	English
Pages (from-to)	809-812
Number of pages	4
Journal	Emerging Infectious Diseases
Volume	23
Issue number	5
DOIs	https://doi.org/10.3201/eid2305.161745
Publication status	Published - 1 May 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3201/eid2305.161745

Cite this

@article{283e57cbffff4a95b8ed4d20a8b952a0,

title = "Increasing macrolide and fluoroquinolone resistance in Mycoplasma genitalium",

abstract = "Escalating resistance to azithromycin and moxifloxacin is being reported for Mycoplasma genitalium in the Asia-Pacific region. Analyzing 140 infections, we found pretreatment fluoroquinolone-resistance mutations in parC (13.6%) and gyrA (5%). ParC S83 changes were associated with moxifloxacin failure. Macrolide/fluoroquinolone-resistance mutations were in 8.6% of specimens, for which recommended therapies would be ineffective.",

author = "Murray, {Gerald L.} and Bradshaw, {Catriona S.} and Melanie Bissessor and Danielewski, {Jennifer A} and Garland, {Suzanne M.} and Jensen, {J{\o}rgen S.} and Fairley, {Christopher K.} and Tabrizi, {Sepehr N.}",

year = "2017",

month = may,

day = "1",

doi = "10.3201/eid2305.161745",

language = "English",

volume = "23",

pages = "809--812",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "5",

}

TY - JOUR

T1 - Increasing macrolide and fluoroquinolone resistance in Mycoplasma genitalium

AU - Murray, Gerald L.

AU - Bradshaw, Catriona S.

AU - Bissessor, Melanie

AU - Danielewski, Jennifer A

AU - Garland, Suzanne M.

AU - Jensen, Jørgen S.

AU - Fairley, Christopher K.

AU - Tabrizi, Sepehr N.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Escalating resistance to azithromycin and moxifloxacin is being reported for Mycoplasma genitalium in the Asia-Pacific region. Analyzing 140 infections, we found pretreatment fluoroquinolone-resistance mutations in parC (13.6%) and gyrA (5%). ParC S83 changes were associated with moxifloxacin failure. Macrolide/fluoroquinolone-resistance mutations were in 8.6% of specimens, for which recommended therapies would be ineffective.

AB - Escalating resistance to azithromycin and moxifloxacin is being reported for Mycoplasma genitalium in the Asia-Pacific region. Analyzing 140 infections, we found pretreatment fluoroquinolone-resistance mutations in parC (13.6%) and gyrA (5%). ParC S83 changes were associated with moxifloxacin failure. Macrolide/fluoroquinolone-resistance mutations were in 8.6% of specimens, for which recommended therapies would be ineffective.

UR - http://www.scopus.com/inward/record.url?scp=85017771129&partnerID=8YFLogxK

U2 - 10.3201/eid2305.161745

DO - 10.3201/eid2305.161745

M3 - Article

AN - SCOPUS:85018628132

SN - 1080-6040

VL - 23

SP - 809

EP - 812

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 5

ER -

Increasing macrolide and fluoroquinolone resistance in Mycoplasma genitalium

Abstract

UN SDGs

Access to Document

Other files and links

Discovery and translation of interventions to control sexually transmitted infections and their consequences

Cite this

Increasing macrolide and fluoroquinolone resistance in Mycoplasma genitalium

Abstract

UN SDGs

Access to Document

Other files and links

Projects

Discovery and translation of interventions to control sexually transmitted infections and their consequences

Cite this