TY - JOUR
T1 - Increased sympathetic activity in children with obstructive sleep apnea: Cardiovascular implications
AU - O'Driscoll, Denise
AU - Horne, Rosemary Sylvia Claire
AU - Davey, Margot
AU - Hope, Sarah
AU - Anderson, Vicki
AU - Trinder, John
AU - Walker, Adrian
AU - Nixon, Gillian
PY - 2011
Y1 - 2011
N2 - BACKGROUND: Obstructive sleep apnea (OSA) is associated with increased sympathetic activity and hypertension in adults. We tested the hypothesis that children with OSA also have increased sympathetic activity as measured by overnight urinary catecholamines, and that this increase is related to the severity of OSA and to blood pressure (BP). METHODS: Seventy snoring children referred for assessment of sleep disordered breathing and 26 healthy non-snoring control children (age range: 3-12years, 59M/37F) were studied. Overnight polysomnography was performed coincident with a 12h overnight urine collection. Urinary catecholamine levels were determined using high performance liquid chromatography (noradrenaline, adrenaline and dopamine, with levels adjusted for creatinine excretion). Simple linear and stepwise multiple linear regressions were used to determine the independent associations between catecholamine levels and age, gender, BMI z-score, systolic BP z-score, diastolic BP z-score, and apnea hypopnea index (AHI). RESULTS: Simple linear regressions revealed significant associations between noradrenaline and AHI (r=0.32) and age (r=-0.20, p
AB - BACKGROUND: Obstructive sleep apnea (OSA) is associated with increased sympathetic activity and hypertension in adults. We tested the hypothesis that children with OSA also have increased sympathetic activity as measured by overnight urinary catecholamines, and that this increase is related to the severity of OSA and to blood pressure (BP). METHODS: Seventy snoring children referred for assessment of sleep disordered breathing and 26 healthy non-snoring control children (age range: 3-12years, 59M/37F) were studied. Overnight polysomnography was performed coincident with a 12h overnight urine collection. Urinary catecholamine levels were determined using high performance liquid chromatography (noradrenaline, adrenaline and dopamine, with levels adjusted for creatinine excretion). Simple linear and stepwise multiple linear regressions were used to determine the independent associations between catecholamine levels and age, gender, BMI z-score, systolic BP z-score, diastolic BP z-score, and apnea hypopnea index (AHI). RESULTS: Simple linear regressions revealed significant associations between noradrenaline and AHI (r=0.32) and age (r=-0.20, p
UR - http://www.ncbi.nlm.nih.gov/pubmed/21521626
U2 - 10.1016/j.sleep.2010.09.015
DO - 10.1016/j.sleep.2010.09.015
M3 - Article
VL - 12
SP - 483
EP - 488
JO - Sleep Medicine
JF - Sleep Medicine
SN - 1389-9457
IS - 5
ER -