Increased sensitivity to broadly neutralizing antibodies of end-stage disease R5 HIV-1 correlates with evolution in Env glycosylation and charge

Marie Borggren, Johanna Repits, Jasminka Sterjovski, Hannes Uchtenhagen, Melissa J Churchill, Anders Karlsson, Jan Albert, Adnane Achour, Paul R Gorry, Eva Maria Fenyo, Marianne Jansson

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Abstract

Our study suggests that R5 HIV-1 variants with increased sensitivity to broadly neutralizing antibodies, including the 2G12 mAb, may emerge in an opportunistic manner during severe immunodeficiency as a consequence of adaptive molecular Env changes, including loss of glycosylation and gain of positive charge.
Original languageEnglish
Article numbere20135
Number of pages9
JournalPLoS ONE
Volume6
Issue number6
DOIs
Publication statusPublished - 2011

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