Increased sensitivity to broadly neutralizing antibodies of end-stage disease R5 HIV-1 correlates with evolution in Env glycosylation and charge

Marie Borggren; Johanna Repits; Jasminka Sterjovski; Hannes Uchtenhagen; Melissa J Churchill; Anders Karlsson; Jan Albert; Adnane Achour; Paul R Gorry; Eva Maria Fenyo; Marianne Jansson

doi:10.1371/journal.pone.0020135

Increased sensitivity to broadly neutralizing antibodies of end-stage disease R5 HIV-1 correlates with evolution in Env glycosylation and charge

Marie Borggren, Johanna Repits, Jasminka Sterjovski, Hannes Uchtenhagen, Melissa J Churchill, Anders Karlsson, Jan Albert, Adnane Achour, Paul R Gorry, Eva Maria Fenyo, Marianne Jansson

Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

15 Citations (Scopus)

Abstract

Our study suggests that R5 HIV-1 variants with increased sensitivity to broadly neutralizing antibodies, including the 2G12 mAb, may emerge in an opportunistic manner during severe immunodeficiency as a consequence of adaptive molecular Env changes, including loss of glycosylation and gain of positive charge.

Original language	English
Article number	e20135
Number of pages	9
Journal	PLoS ONE
Volume	6
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0020135
Publication status	Published - 2011

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Borggren, M., Repits, J., Sterjovski, J., Uchtenhagen, H., Churchill, M. J., Karlsson, A., Albert, J., Achour, A., Gorry, P. R., Fenyo, E. M., & Jansson, M. (2011). Increased sensitivity to broadly neutralizing antibodies of end-stage disease R5 HIV-1 correlates with evolution in Env glycosylation and charge. PLoS ONE, 6(6), [e20135]. https://doi.org/10.1371/journal.pone.0020135

Borggren, Marie ; Repits, Johanna ; Sterjovski, Jasminka ; Uchtenhagen, Hannes ; Churchill, Melissa J ; Karlsson, Anders ; Albert, Jan ; Achour, Adnane ; Gorry, Paul R ; Fenyo, Eva Maria ; Jansson, Marianne. / Increased sensitivity to broadly neutralizing antibodies of end-stage disease R5 HIV-1 correlates with evolution in Env glycosylation and charge. In: PLoS ONE. 2011 ; Vol. 6, No. 6.

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abstract = "Our study suggests that R5 HIV-1 variants with increased sensitivity to broadly neutralizing antibodies, including the 2G12 mAb, may emerge in an opportunistic manner during severe immunodeficiency as a consequence of adaptive molecular Env changes, including loss of glycosylation and gain of positive charge.",

author = "Marie Borggren and Johanna Repits and Jasminka Sterjovski and Hannes Uchtenhagen and Churchill, {Melissa J} and Anders Karlsson and Jan Albert and Adnane Achour and Gorry, {Paul R} and Fenyo, {Eva Maria} and Marianne Jansson",

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Borggren, M, Repits, J, Sterjovski, J, Uchtenhagen, H, Churchill, MJ, Karlsson, A, Albert, J, Achour, A, Gorry, PR, Fenyo, EM & Jansson, M 2011, 'Increased sensitivity to broadly neutralizing antibodies of end-stage disease R5 HIV-1 correlates with evolution in Env glycosylation and charge', PLoS ONE, vol. 6, no. 6, e20135. https://doi.org/10.1371/journal.pone.0020135

Increased sensitivity to broadly neutralizing antibodies of end-stage disease R5 HIV-1 correlates with evolution in Env glycosylation and charge. / Borggren, Marie; Repits, Johanna; Sterjovski, Jasminka; Uchtenhagen, Hannes; Churchill, Melissa J; Karlsson, Anders; Albert, Jan; Achour, Adnane; Gorry, Paul R; Fenyo, Eva Maria; Jansson, Marianne.

In: PLoS ONE, Vol. 6, No. 6, e20135, 2011.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Churchill, Melissa J

AU - Karlsson, Anders

AU - Albert, Jan

AU - Achour, Adnane

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AU - Fenyo, Eva Maria

AU - Jansson, Marianne

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