Increased myocardial prevalence of C-reactive protein in human coronary heart disease: direct effects on microvessel density and endothelial cell survival

Mandar Joshi; Liyue Tong; Angela C Cook; Brandon L Schanbacher; Hong Huang; Bing Han; Leona W Ayers; John Anthony Bauer

doi:10.1016/j.carpath.2011.12.003

Increased myocardial prevalence of C-reactive protein in human coronary heart disease: direct effects on microvessel density and endothelial cell survival

Mandar Joshi, Liyue Tong, Angela C Cook, Brandon L Schanbacher, Hong Huang, Bing Han, Leona W Ayers, John Anthony Bauer

Hudson Institute - The Ritchie Centre

Research output: Contribution to journal › Article › Research › peer-review

22 Citations (Scopus)

Abstract

Elevated plasma C-reactive protein (CRP) is a biomarker of cardiovascular diseases (CVDs), but its potential roles as a participant of the disease process are not well defined. Although early endothelial cell injury and dysfunction are recognized events in CVD, the initiating events are not well established. Here we investigated the local myocardial CRP levels and cardiac microvessel densities in control and CVD tissue samples. Using in vitro methodologies, we investigated the direct effects of CRP on human endothelial cells. METHODS: Cardiac specimens were collected at autopsy within 4 h of death and were classified as normal controls or documented evidence of CVD. The regional prevalence of CRP and the cardiac microvessels (

Original language	English
Pages (from-to)	428 - 435
Number of pages	8
Journal	Cardiovascular Pathology
Volume	21
Issue number	5
DOIs	https://doi.org/10.1016/j.carpath.2011.12.003
Publication status	Published - 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.carpath.2011.12.003

Cite this

@article{5997672633194d07a0cc0b014de8c8d2,

title = "Increased myocardial prevalence of C-reactive protein in human coronary heart disease: direct effects on microvessel density and endothelial cell survival",

abstract = "Elevated plasma C-reactive protein (CRP) is a biomarker of cardiovascular diseases (CVDs), but its potential roles as a participant of the disease process are not well defined. Although early endothelial cell injury and dysfunction are recognized events in CVD, the initiating events are not well established. Here we investigated the local myocardial CRP levels and cardiac microvessel densities in control and CVD tissue samples. Using in vitro methodologies, we investigated the direct effects of CRP on human endothelial cells. METHODS: Cardiac specimens were collected at autopsy within 4 h of death and were classified as normal controls or documented evidence of CVD. The regional prevalence of CRP and the cardiac microvessels (",

author = "Mandar Joshi and Liyue Tong and Cook, {Angela C} and Schanbacher, {Brandon L} and Hong Huang and Bing Han and Ayers, {Leona W} and Bauer, {John Anthony}",

year = "2012",

doi = "10.1016/j.carpath.2011.12.003",

language = "English",

volume = "21",

pages = "428 -- 435",

journal = "Cardiovascular Pathology",

issn = "1054-8807",

publisher = "Elsevier",

number = "5",

}

TY - JOUR

T1 - Increased myocardial prevalence of C-reactive protein in human coronary heart disease: direct effects on microvessel density and endothelial cell survival

AU - Joshi, Mandar

AU - Tong, Liyue

AU - Cook, Angela C

AU - Schanbacher, Brandon L

AU - Huang, Hong

AU - Han, Bing

AU - Ayers, Leona W

AU - Bauer, John Anthony

PY - 2012

Y1 - 2012

N2 - Elevated plasma C-reactive protein (CRP) is a biomarker of cardiovascular diseases (CVDs), but its potential roles as a participant of the disease process are not well defined. Although early endothelial cell injury and dysfunction are recognized events in CVD, the initiating events are not well established. Here we investigated the local myocardial CRP levels and cardiac microvessel densities in control and CVD tissue samples. Using in vitro methodologies, we investigated the direct effects of CRP on human endothelial cells. METHODS: Cardiac specimens were collected at autopsy within 4 h of death and were classified as normal controls or documented evidence of CVD. The regional prevalence of CRP and the cardiac microvessels (

AB - Elevated plasma C-reactive protein (CRP) is a biomarker of cardiovascular diseases (CVDs), but its potential roles as a participant of the disease process are not well defined. Although early endothelial cell injury and dysfunction are recognized events in CVD, the initiating events are not well established. Here we investigated the local myocardial CRP levels and cardiac microvessel densities in control and CVD tissue samples. Using in vitro methodologies, we investigated the direct effects of CRP on human endothelial cells. METHODS: Cardiac specimens were collected at autopsy within 4 h of death and were classified as normal controls or documented evidence of CVD. The regional prevalence of CRP and the cardiac microvessels (

UR - http://www.sciencedirect.com/science/article/pii/S1054880711001554

U2 - 10.1016/j.carpath.2011.12.003

DO - 10.1016/j.carpath.2011.12.003

M3 - Article

SN - 1054-8807

VL - 21

SP - 428

EP - 435

JO - Cardiovascular Pathology

JF - Cardiovascular Pathology

IS - 5

ER -

Increased myocardial prevalence of C-reactive protein in human coronary heart disease: direct effects on microvessel density and endothelial cell survival

Abstract

UN SDGs

Access to Document

Other files and links

Cite this