Increased cortical recruitment in Huntington's disease using a Simon task

Nellie Georgiou-Karistianis, Anusha Sritharan, Maree Farrow, Ross Cunnington, Julie C Stout, John Lockyer Bradshaw, Andrew J Churchyard, Tamara-Leigh Brawn, Phyllis Chua, Edmond Chiu, Dhananjay Raghavan Thiruvady, Gary Egan

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Cognitive deficits in Huntington s disease (HD) have been attributed to neuronal degeneration within the striatum; however, postmortem and structural imaging studies have revealed more widespread morphological changes. To examine the impact of HD-related changes in regions outside the striatum, we used functional magnetic resonance imaging (fMRI) in HD to examine brain activation patterns using a Simon task that required a button press response to either congruent or incongruent arrow stimuli. Twenty mild to moderate stage HD patients and 17 healthy controls were scanned using a 3 T GE scanner. Data analysis involved the use of statistical parametric mapping software with a random effects analysis model to investigate group differences brain activation patterns compared to baseline. HD patients recruited frontal and parietal cortical regions to perform the task, and also showed significantly greater activation, compared to controls, in the caudal anterior cingulate, insula, inferior parietal lobules, superior temporal gyrus bilaterally, right inferior frontal gyrus, right precuneus/superior parietal lobule, left precentral gyrus, and left dorsal premotor cortex. The significantly increased activation in anterior cingulate-frontal-motor-parietal cortex in HD may represent a primary dysfunction due to direct cell loss or damage in cortical regions, and/or a secondary compensatory mechanism of increased cortical recruitment due to primary striatal deficits.
Original languageEnglish
Pages (from-to)1791 - 1800
Number of pages10
JournalNeuropsychologia
Volume45
Issue number8
Publication statusPublished - 2007

Cite this

Georgiou-Karistianis, Nellie ; Sritharan, Anusha ; Farrow, Maree ; Cunnington, Ross ; Stout, Julie C ; Bradshaw, John Lockyer ; Churchyard, Andrew J ; Brawn, Tamara-Leigh ; Chua, Phyllis ; Chiu, Edmond ; Thiruvady, Dhananjay Raghavan ; Egan, Gary. / Increased cortical recruitment in Huntington's disease using a Simon task. In: Neuropsychologia. 2007 ; Vol. 45, No. 8. pp. 1791 - 1800.
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abstract = "Cognitive deficits in Huntington s disease (HD) have been attributed to neuronal degeneration within the striatum; however, postmortem and structural imaging studies have revealed more widespread morphological changes. To examine the impact of HD-related changes in regions outside the striatum, we used functional magnetic resonance imaging (fMRI) in HD to examine brain activation patterns using a Simon task that required a button press response to either congruent or incongruent arrow stimuli. Twenty mild to moderate stage HD patients and 17 healthy controls were scanned using a 3 T GE scanner. Data analysis involved the use of statistical parametric mapping software with a random effects analysis model to investigate group differences brain activation patterns compared to baseline. HD patients recruited frontal and parietal cortical regions to perform the task, and also showed significantly greater activation, compared to controls, in the caudal anterior cingulate, insula, inferior parietal lobules, superior temporal gyrus bilaterally, right inferior frontal gyrus, right precuneus/superior parietal lobule, left precentral gyrus, and left dorsal premotor cortex. The significantly increased activation in anterior cingulate-frontal-motor-parietal cortex in HD may represent a primary dysfunction due to direct cell loss or damage in cortical regions, and/or a secondary compensatory mechanism of increased cortical recruitment due to primary striatal deficits.",
author = "Nellie Georgiou-Karistianis and Anusha Sritharan and Maree Farrow and Ross Cunnington and Stout, {Julie C} and Bradshaw, {John Lockyer} and Churchyard, {Andrew J} and Tamara-Leigh Brawn and Phyllis Chua and Edmond Chiu and Thiruvady, {Dhananjay Raghavan} and Gary Egan",
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Georgiou-Karistianis, N, Sritharan, A, Farrow, M, Cunnington, R, Stout, JC, Bradshaw, JL, Churchyard, AJ, Brawn, T-L, Chua, P, Chiu, E, Thiruvady, DR & Egan, G 2007, 'Increased cortical recruitment in Huntington's disease using a Simon task', Neuropsychologia, vol. 45, no. 8, pp. 1791 - 1800.

Increased cortical recruitment in Huntington's disease using a Simon task. / Georgiou-Karistianis, Nellie; Sritharan, Anusha; Farrow, Maree; Cunnington, Ross; Stout, Julie C; Bradshaw, John Lockyer; Churchyard, Andrew J; Brawn, Tamara-Leigh; Chua, Phyllis; Chiu, Edmond; Thiruvady, Dhananjay Raghavan; Egan, Gary.

In: Neuropsychologia, Vol. 45, No. 8, 2007, p. 1791 - 1800.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Georgiou-Karistianis, Nellie

AU - Sritharan, Anusha

AU - Farrow, Maree

AU - Cunnington, Ross

AU - Stout, Julie C

AU - Bradshaw, John Lockyer

AU - Churchyard, Andrew J

AU - Brawn, Tamara-Leigh

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AU - Thiruvady, Dhananjay Raghavan

AU - Egan, Gary

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