Increased brain histamine levels in Parkinson's disease but not in multiple system atrophy

J. O. Rinne, O. V. Anichtchik, K. S. Eriksson, J. Kaslin, L. Tuomisto, H. Kalimo, M. Röyttä, P. Panula

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Abstract

We investigated histamine concentration in post-mortem brain samples of patients with Parkinson's disease (PD, n = 24), multiple system atrophy (MSA, n = 8) and age-matched controls (n = 27). Histamine concentrations were significantly increased in the putamen (to 159% of the control mean), substantia nigra pars compacta (to 201%), internal globus pallidus (to 234%) and external globus pallidus (to 200%), i.e. in areas which play a crucial role in the motor behaviour and which show typical functional alterations in PD. In MSA no significant differences were seen. Tele-methylhistamine (histamine metabolite) concentrations were unchanged in PD. These results indicate that histamine concentration, but not its metabolism is increased in PD, but not in MSA. This finding may have implications in developing new drug therapies for PD and in differential diagnosis between PD and MSA.

Original languageEnglish
Pages (from-to)954-960
Number of pages7
JournalJournal of Neurochemistry
Volume81
Issue number5
DOIs
Publication statusPublished - 2002
Externally publishedYes

Keywords

  • Histamine
  • Multiple system atrophy
  • Parkinson's disease
  • Tele-methylhistamine

Cite this

Rinne, J. O., Anichtchik, O. V., Eriksson, K. S., Kaslin, J., Tuomisto, L., Kalimo, H., Röyttä, M., & Panula, P. (2002). Increased brain histamine levels in Parkinson's disease but not in multiple system atrophy. Journal of Neurochemistry, 81(5), 954-960. https://doi.org/10.1046/j.1471-4159.2002.00871.x