Increased body mass index in parent-child dyads predicts the offspring risk of meeting bariatric surgery criteria

Markus Juonala, Matthew A. Sabin, David Burgner, Michael M H Cheung, Mika Kähönen, Nina Hutri-Kähönen, Terho Lehtimäki, Eero Jokinen, Juha Koskinen, Päivi Tossavainen, Tomi Laitinen, Jorma S A Viikari, Olli T Raitakari, Costan G. Magnussen

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Context: Obesity in children is a major public health concern. Objective: This study examined the value of using parent-child dyads' adiposity status for predicting the individual's later eligibility for bariatric surgery (EBS). Design, Setting, and Participants: The cohort consisted of 2647 individuals from the longitudinal Cardiovascular Risk inYoungFinns Study. Baseline information includedownandparentalbodymassindex (BMI) in 1980 (children aged 3-18 years), whereas adult follow-up assessment examined EBS 21-31 years later. Main Outcome Measure: EBS in adulthood was defined as: 1) BMI greater than 40 kg/m2 or 2) BMI greater than 35 kg/m2 with at least one of the following metabolic complications: type 2 diabetes, hypertension, or dyslipidemia. Results: Addition of parents' BMI improved the prediction of adulthood EBS compared to the model including child's BMI, age, and sex (area under the curve values [95% confidence interval] (0.80 [0.74-0.85] vs 0.74 [0.68-0.81], P = .003). Obese children with an obese parent had a 21.2% chance of being EBS in adulthood. Compared to nonobese families, the risk ratio for EBS was 14.2 (95% confidence interval 8.0-25.2, P < .001) in obese children with an obese parent. The absolute risk of EBS was 30.9% if both child and parent were obese on more than one childhood assessment compared to 15.2% if they were obese only once, or 2.1% if they were never obese (P = .05). Conclusions: These longitudinal data show that a combination of the child's and parents' BMI at baseline assessment is a useful predictive tool for assessing later EBS, and highlights the importance of accounting for parental BMI in the assessment of child obesity.

Original languageEnglish
Pages (from-to)4257-4263
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume100
Issue number11
DOIs
Publication statusPublished - 1 Nov 2015

Cite this

Juonala, Markus ; Sabin, Matthew A. ; Burgner, David ; Cheung, Michael M H ; Kähönen, Mika ; Hutri-Kähönen, Nina ; Lehtimäki, Terho ; Jokinen, Eero ; Koskinen, Juha ; Tossavainen, Päivi ; Laitinen, Tomi ; Viikari, Jorma S A ; Raitakari, Olli T ; Magnussen, Costan G. / Increased body mass index in parent-child dyads predicts the offspring risk of meeting bariatric surgery criteria. In: Journal of Clinical Endocrinology and Metabolism. 2015 ; Vol. 100, No. 11. pp. 4257-4263.
@article{13f1a373754e40fcbb1fe6bab8ccc0cc,
title = "Increased body mass index in parent-child dyads predicts the offspring risk of meeting bariatric surgery criteria",
abstract = "Context: Obesity in children is a major public health concern. Objective: This study examined the value of using parent-child dyads' adiposity status for predicting the individual's later eligibility for bariatric surgery (EBS). Design, Setting, and Participants: The cohort consisted of 2647 individuals from the longitudinal Cardiovascular Risk inYoungFinns Study. Baseline information includedownandparentalbodymassindex (BMI) in 1980 (children aged 3-18 years), whereas adult follow-up assessment examined EBS 21-31 years later. Main Outcome Measure: EBS in adulthood was defined as: 1) BMI greater than 40 kg/m2 or 2) BMI greater than 35 kg/m2 with at least one of the following metabolic complications: type 2 diabetes, hypertension, or dyslipidemia. Results: Addition of parents' BMI improved the prediction of adulthood EBS compared to the model including child's BMI, age, and sex (area under the curve values [95{\%} confidence interval] (0.80 [0.74-0.85] vs 0.74 [0.68-0.81], P = .003). Obese children with an obese parent had a 21.2{\%} chance of being EBS in adulthood. Compared to nonobese families, the risk ratio for EBS was 14.2 (95{\%} confidence interval 8.0-25.2, P < .001) in obese children with an obese parent. The absolute risk of EBS was 30.9{\%} if both child and parent were obese on more than one childhood assessment compared to 15.2{\%} if they were obese only once, or 2.1{\%} if they were never obese (P = .05). Conclusions: These longitudinal data show that a combination of the child's and parents' BMI at baseline assessment is a useful predictive tool for assessing later EBS, and highlights the importance of accounting for parental BMI in the assessment of child obesity.",
author = "Markus Juonala and Sabin, {Matthew A.} and David Burgner and Cheung, {Michael M H} and Mika K{\"a}h{\"o}nen and Nina Hutri-K{\"a}h{\"o}nen and Terho Lehtim{\"a}ki and Eero Jokinen and Juha Koskinen and P{\"a}ivi Tossavainen and Tomi Laitinen and Viikari, {Jorma S A} and Raitakari, {Olli T} and Magnussen, {Costan G.}",
year = "2015",
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doi = "10.1210/jc.2015-2524",
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Juonala, M, Sabin, MA, Burgner, D, Cheung, MMH, Kähönen, M, Hutri-Kähönen, N, Lehtimäki, T, Jokinen, E, Koskinen, J, Tossavainen, P, Laitinen, T, Viikari, JSA, Raitakari, OT & Magnussen, CG 2015, 'Increased body mass index in parent-child dyads predicts the offspring risk of meeting bariatric surgery criteria', Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 11, pp. 4257-4263. https://doi.org/10.1210/jc.2015-2524

Increased body mass index in parent-child dyads predicts the offspring risk of meeting bariatric surgery criteria. / Juonala, Markus; Sabin, Matthew A.; Burgner, David; Cheung, Michael M H; Kähönen, Mika; Hutri-Kähönen, Nina; Lehtimäki, Terho; Jokinen, Eero; Koskinen, Juha; Tossavainen, Päivi; Laitinen, Tomi; Viikari, Jorma S A; Raitakari, Olli T; Magnussen, Costan G.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 100, No. 11, 01.11.2015, p. 4257-4263.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Increased body mass index in parent-child dyads predicts the offspring risk of meeting bariatric surgery criteria

AU - Juonala, Markus

AU - Sabin, Matthew A.

AU - Burgner, David

AU - Cheung, Michael M H

AU - Kähönen, Mika

AU - Hutri-Kähönen, Nina

AU - Lehtimäki, Terho

AU - Jokinen, Eero

AU - Koskinen, Juha

AU - Tossavainen, Päivi

AU - Laitinen, Tomi

AU - Viikari, Jorma S A

AU - Raitakari, Olli T

AU - Magnussen, Costan G.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Context: Obesity in children is a major public health concern. Objective: This study examined the value of using parent-child dyads' adiposity status for predicting the individual's later eligibility for bariatric surgery (EBS). Design, Setting, and Participants: The cohort consisted of 2647 individuals from the longitudinal Cardiovascular Risk inYoungFinns Study. Baseline information includedownandparentalbodymassindex (BMI) in 1980 (children aged 3-18 years), whereas adult follow-up assessment examined EBS 21-31 years later. Main Outcome Measure: EBS in adulthood was defined as: 1) BMI greater than 40 kg/m2 or 2) BMI greater than 35 kg/m2 with at least one of the following metabolic complications: type 2 diabetes, hypertension, or dyslipidemia. Results: Addition of parents' BMI improved the prediction of adulthood EBS compared to the model including child's BMI, age, and sex (area under the curve values [95% confidence interval] (0.80 [0.74-0.85] vs 0.74 [0.68-0.81], P = .003). Obese children with an obese parent had a 21.2% chance of being EBS in adulthood. Compared to nonobese families, the risk ratio for EBS was 14.2 (95% confidence interval 8.0-25.2, P < .001) in obese children with an obese parent. The absolute risk of EBS was 30.9% if both child and parent were obese on more than one childhood assessment compared to 15.2% if they were obese only once, or 2.1% if they were never obese (P = .05). Conclusions: These longitudinal data show that a combination of the child's and parents' BMI at baseline assessment is a useful predictive tool for assessing later EBS, and highlights the importance of accounting for parental BMI in the assessment of child obesity.

AB - Context: Obesity in children is a major public health concern. Objective: This study examined the value of using parent-child dyads' adiposity status for predicting the individual's later eligibility for bariatric surgery (EBS). Design, Setting, and Participants: The cohort consisted of 2647 individuals from the longitudinal Cardiovascular Risk inYoungFinns Study. Baseline information includedownandparentalbodymassindex (BMI) in 1980 (children aged 3-18 years), whereas adult follow-up assessment examined EBS 21-31 years later. Main Outcome Measure: EBS in adulthood was defined as: 1) BMI greater than 40 kg/m2 or 2) BMI greater than 35 kg/m2 with at least one of the following metabolic complications: type 2 diabetes, hypertension, or dyslipidemia. Results: Addition of parents' BMI improved the prediction of adulthood EBS compared to the model including child's BMI, age, and sex (area under the curve values [95% confidence interval] (0.80 [0.74-0.85] vs 0.74 [0.68-0.81], P = .003). Obese children with an obese parent had a 21.2% chance of being EBS in adulthood. Compared to nonobese families, the risk ratio for EBS was 14.2 (95% confidence interval 8.0-25.2, P < .001) in obese children with an obese parent. The absolute risk of EBS was 30.9% if both child and parent were obese on more than one childhood assessment compared to 15.2% if they were obese only once, or 2.1% if they were never obese (P = .05). Conclusions: These longitudinal data show that a combination of the child's and parents' BMI at baseline assessment is a useful predictive tool for assessing later EBS, and highlights the importance of accounting for parental BMI in the assessment of child obesity.

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U2 - 10.1210/jc.2015-2524

DO - 10.1210/jc.2015-2524

M3 - Article

VL - 100

SP - 4257

EP - 4263

JO - Journal of Clinical Endocrinology and Metablism

JF - Journal of Clinical Endocrinology and Metablism

SN - 0021-972X

IS - 11

ER -