Incorporation of [U-13C]glycerol defines plausible early steps for the biosynthesis of methylenomycin A in Streptomyces coelicolor A3(2)

G. L. Challis; K. F. Chater

doi:10.1039/b101615f

Incorporation of [U-¹³C]glycerol defines plausible early steps for the biosynthesis of methylenomycin A in Streptomyces coelicolor A3(2)

G. L. Challis, K. F. Chater

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Abstract

Incorporation of [U-¹³C]glycerol into the linear plasmid-encoded secondary metabolite methylenomycin A, both intact and indirectly via metabolism to acetyl CoA, was observed in Streptomyces coelicolor suggesting plausible early biosynthetic steps for this unusual antibiotic.

Original language	English
Pages (from-to)	935-936
Number of pages	2
Journal	Chemical Communications
Issue number	10
DOIs	https://doi.org/10.1039/b101615f
Publication status	Published - 21 May 2001
Externally published	Yes

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title = "Incorporation of [U-13C]glycerol defines plausible early steps for the biosynthesis of methylenomycin A in Streptomyces coelicolor A3(2)",

abstract = "Incorporation of [U-13C]glycerol into the linear plasmid-encoded secondary metabolite methylenomycin A, both intact and indirectly via metabolism to acetyl CoA, was observed in Streptomyces coelicolor suggesting plausible early biosynthetic steps for this unusual antibiotic.",

author = "Challis, {G. L.} and Chater, {K. F.}",

year = "2001",

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doi = "10.1039/b101615f",

language = "English",

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journal = "Chemical Communications",

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publisher = "The Royal Society of Chemistry",

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AU - Challis, G. L.

AU - Chater, K. F.

PY - 2001/5/21

Y1 - 2001/5/21

N2 - Incorporation of [U-13C]glycerol into the linear plasmid-encoded secondary metabolite methylenomycin A, both intact and indirectly via metabolism to acetyl CoA, was observed in Streptomyces coelicolor suggesting plausible early biosynthetic steps for this unusual antibiotic.

AB - Incorporation of [U-13C]glycerol into the linear plasmid-encoded secondary metabolite methylenomycin A, both intact and indirectly via metabolism to acetyl CoA, was observed in Streptomyces coelicolor suggesting plausible early biosynthetic steps for this unusual antibiotic.

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U2 - 10.1039/b101615f

DO - 10.1039/b101615f

M3 - Article

AN - SCOPUS:0035926770

SN - 1359-7345

SP - 935

EP - 936

JO - Chemical Communications

JF - Chemical Communications

IS - 10

ER -

Incorporation of [U-13C]glycerol defines plausible early steps for the biosynthesis of methylenomycin A in Streptomyces coelicolor A3(2)

Abstract

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Incorporation of [U-¹³C]glycerol defines plausible early steps for the biosynthesis of methylenomycin A in Streptomyces coelicolor A3(2)