Incorporation of Homochirality into a Zeolitic Imidazolate Framework Membrane for Efficient Chiral Separation

Jun Yong Chan, Huacheng Zhang, Yada Nolvachai, Yaoxin Hu, Haijin Zhu, Maria Forsyth, Qinfen Gu, David E. Hoke, Xiwang Zhang, Philip J. Marriott, Huanting Wang

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Homochiral metal–organic frameworks (MOFs) have gained much attention because of their chiral properties and disposition for chiral separation. However, the fabrication of high-quality homochiral MOF membranes remains challenging because of the difficulty in controlling growth of MOF membranes with chiral functionalities. A homochiral zeolitic imidazolate framework-8 (ZIF-8) membrane is reported for efficient chiral separation. The membrane is synthesized by incorporating a natural amino acid, l-histidine (l-His), into the framework of ZIF-8. The homochiral l-His-ZIF-8 membrane exhibits a good selectivity for the R-enantiomer of 1-phenylethanol over the S-enantiomer, showing a high enantiomeric excess value up to 76 %.

Original languageEnglish
Pages (from-to)17130-17134
Number of pages5
JournalAngewandte Chemie - International Edition
Volume57
Issue number52
DOIs
Publication statusPublished - 21 Dec 2018

Keywords

  • chiral resolution
  • chirality
  • homochiral
  • membrane separation
  • metal–organic frameworks

Cite this

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title = "Incorporation of Homochirality into a Zeolitic Imidazolate Framework Membrane for Efficient Chiral Separation",
abstract = "Homochiral metal–organic frameworks (MOFs) have gained much attention because of their chiral properties and disposition for chiral separation. However, the fabrication of high-quality homochiral MOF membranes remains challenging because of the difficulty in controlling growth of MOF membranes with chiral functionalities. A homochiral zeolitic imidazolate framework-8 (ZIF-8) membrane is reported for efficient chiral separation. The membrane is synthesized by incorporating a natural amino acid, l-histidine (l-His), into the framework of ZIF-8. The homochiral l-His-ZIF-8 membrane exhibits a good selectivity for the R-enantiomer of 1-phenylethanol over the S-enantiomer, showing a high enantiomeric excess value up to 76 {\%}.",
keywords = "chiral resolution, chirality, homochiral, membrane separation, metal–organic frameworks",
author = "Chan, {Jun Yong} and Huacheng Zhang and Yada Nolvachai and Yaoxin Hu and Haijin Zhu and Maria Forsyth and Qinfen Gu and Hoke, {David E.} and Xiwang Zhang and Marriott, {Philip J.} and Huanting Wang",
year = "2018",
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language = "English",
volume = "57",
pages = "17130--17134",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "Wiley-Blackwell",
number = "52",

}

Incorporation of Homochirality into a Zeolitic Imidazolate Framework Membrane for Efficient Chiral Separation. / Chan, Jun Yong; Zhang, Huacheng; Nolvachai, Yada; Hu, Yaoxin; Zhu, Haijin; Forsyth, Maria; Gu, Qinfen; Hoke, David E.; Zhang, Xiwang; Marriott, Philip J.; Wang, Huanting.

In: Angewandte Chemie - International Edition, Vol. 57, No. 52, 21.12.2018, p. 17130-17134.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Incorporation of Homochirality into a Zeolitic Imidazolate Framework Membrane for Efficient Chiral Separation

AU - Chan, Jun Yong

AU - Zhang, Huacheng

AU - Nolvachai, Yada

AU - Hu, Yaoxin

AU - Zhu, Haijin

AU - Forsyth, Maria

AU - Gu, Qinfen

AU - Hoke, David E.

AU - Zhang, Xiwang

AU - Marriott, Philip J.

AU - Wang, Huanting

PY - 2018/12/21

Y1 - 2018/12/21

N2 - Homochiral metal–organic frameworks (MOFs) have gained much attention because of their chiral properties and disposition for chiral separation. However, the fabrication of high-quality homochiral MOF membranes remains challenging because of the difficulty in controlling growth of MOF membranes with chiral functionalities. A homochiral zeolitic imidazolate framework-8 (ZIF-8) membrane is reported for efficient chiral separation. The membrane is synthesized by incorporating a natural amino acid, l-histidine (l-His), into the framework of ZIF-8. The homochiral l-His-ZIF-8 membrane exhibits a good selectivity for the R-enantiomer of 1-phenylethanol over the S-enantiomer, showing a high enantiomeric excess value up to 76 %.

AB - Homochiral metal–organic frameworks (MOFs) have gained much attention because of their chiral properties and disposition for chiral separation. However, the fabrication of high-quality homochiral MOF membranes remains challenging because of the difficulty in controlling growth of MOF membranes with chiral functionalities. A homochiral zeolitic imidazolate framework-8 (ZIF-8) membrane is reported for efficient chiral separation. The membrane is synthesized by incorporating a natural amino acid, l-histidine (l-His), into the framework of ZIF-8. The homochiral l-His-ZIF-8 membrane exhibits a good selectivity for the R-enantiomer of 1-phenylethanol over the S-enantiomer, showing a high enantiomeric excess value up to 76 %.

KW - chiral resolution

KW - chirality

KW - homochiral

KW - membrane separation

KW - metal–organic frameworks

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