Incorporation of homochirality into a zeolitic imidazolate framework membrane for efficient chiral separation

Junyong Chan, Huacheng Zhang, Yada Nolvachai, Yaoxin Hu, Haijin Zhu, Maria Forsyth, Qinfen Gu, David E. Hoke, Xiwang Zhang, Philip J. Marriot, Huanting Wang

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Homochiral metal–organic frameworks (MOFs) have gained much attention because of their chiral properties and disposition for chiral separation. However, the fabrication of high-quality homochiral MOF membranes remains challenging because of the difficulty in controlling growth of MOF membranes with chiral functionalities. Ahomochiral zeolitic imidazolate framework-8 (ZIF-8) membrane is reported for efficient chiral separation. The membrane is synthesized by incorporating anatural amino acid, l-histidine (l-His), into the framework of ZIF-8. The homochiral l-His-ZIF-8 membrane exhibits a good selectivity for the R-enantiomer of 1-phenylethanol over the S-enantiomer, showing a high enantiomeric excess value up to 76%.

Original languageEnglish
Pages (from-to)17376-17380
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number52
Publication statusPublished - 21 Dec 2018


  • chiral resolution
  • chirality
  • homochiral
  • membrane separation
  • metal–organic frameworks

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