TY - JOUR
T1 - Incidence, risk factors, and temporal trends of small intestinal cancer
T2 - a global analysis of cancer registries
AU - Huang, Junjie
AU - Chan, Sze Chai
AU - Fung, Yat Ching
AU - Mak, Fung Yu
AU - Lok, Veeleah
AU - Zhang, Lin
AU - Lin, Xu
AU - Lucero-Prisno III, Don Eliseo
AU - Xu, Wanghong
AU - Zheng, Zhi-Jie
AU - Elcarte, Edmar
AU - Withers, Mellissa
AU - Wong, Martin C.S.
AU - NCD Global Health Research Group
AU - Association of Pacific Rim Universities (APRU)
N1 - Funding Information:
The NCD Global Health Research Group, Association of Pacific Rim Universities includes Mellissa Withers,1 Martin C. S. Wong,2 Junjie Huang,2 Edmar Elcarte,3 Sze Chai Chan,2 Yat Ching Fung,2 Fung Yu Mak,2 Veeleah Lok,4 Lin Zhang,5 Xu Lin,6 Don Eliseo Lucero-Prisno III,7 Wanghong Xu,8 and Zhi-Jie Zheng9; from the 1University of Southern California, Los Angeles, California; 2Chinese University of Hong Kong, Hong Kong SAR, China; 3University of the Philippines, Manila, the Philippines; 4Karolinska Institute, Stockholm, Sweden; 5The University of Melbourne, Victoria, Australia; 6Zhejiang University, Hangzhou, Zhejiang, China; 7London School of Hygiene and Tropical Medicine, London, United Kingdom; 8Fudan University, Shanghai, China; and 9Peking University, Beijing, China. Junjie Huang, MD, PhD (Conceptualization: Lead; Supervision: Lead; Writing – review & editing: Lead). Sze Chai Chan, MSc (Data curation: Lead; Formal analysis: Lead; Writing – original draft: Equal). Yat Ching Fung, BSocSc (Writing – original draft: Equal). Fung Yu Mak, BSocSc (Writing – original draft: Equal). Veeleah Lok, MPH (Writing – review & editing: Equal). Lin Zhang, PhD (Writing – review & editing: Equal). Xu Lin, MD (Writing – review & editing: Equal). Don Eliseo Lucero-Prisno III, PhD (Writing – review & editing: Equal). Wanghong Xu, PhD (Writing – review & editing: Equal). Zhi-Jie Zheng, PhD (Writing – review & editing: Equal). Edmar Elcarte, MA (Writing – review & editing: Equal). Mellissa Withers, PhD (Writing – review & editing: Equal). Martin C. S. Wong, MD (Conceptualization: Lead; Supervision: Lead; Writing – review & editing: Equal).
Publisher Copyright:
© 2023 The Authors
PY - 2023/9
Y1 - 2023/9
N2 - Background & Aims: Small intestinal cancer is a rare cancer, with limited studies exploring its epidemiology. To our knowledge, this study is the first effort to comprehensively analyze the incidence, risk factors, and trends for small intestinal cancer by sex, age, and country. Methods: Global Cancer Observatory, Cancer Incidence in Five Continents Plus, and Global Burden of Disease were accessed to estimate the age-standardized rates of small intestinal cancer incidence (International Classification of Diseases, 10th Revision, Clinical Modification: C17) and prevalence of lifestyle risk factors, metabolic risk factors, and inflammatory bowel disease (IBD). Risk factor associations were assessed by linear and logistic regressions. Average annual percent change was calculated using joinpoint regression. Results: A total of 64,477 small intestinal cancer cases (age-standardized rate, 0.60 per 100,000) were estimated globally in 2020, with a higher disease burden found in North America (1.4). Higher small intestinal cancer incidence was associated with higher human development index; gross domestic product; and prevalence of smoking, alcohol drinking, physical inactivity, obesity, diabetes, lipid disorder, and IBD (β = 0.008–0.198; odds ratios, 1.07–10.01). There was an overall increasing trend of small intestinal cancer incidence (average annual percent change, 2.20–21.67), and the increasing trend was comparable among the 2 sexes but more evident in the older population aged 50–74 years than in the younger population aged 15–49 years. Conclusion: There was a substantial geographic disparity in the burden of small intestinal cancer, with higher incidence observed in countries with higher human development index; gross domestic product; and prevalence of unhealthy lifestyle habits, metabolic disorders, and IBD. There was an overall increasing trend in small intestinal cancer incidence, calling for the development of preventive strategies.
AB - Background & Aims: Small intestinal cancer is a rare cancer, with limited studies exploring its epidemiology. To our knowledge, this study is the first effort to comprehensively analyze the incidence, risk factors, and trends for small intestinal cancer by sex, age, and country. Methods: Global Cancer Observatory, Cancer Incidence in Five Continents Plus, and Global Burden of Disease were accessed to estimate the age-standardized rates of small intestinal cancer incidence (International Classification of Diseases, 10th Revision, Clinical Modification: C17) and prevalence of lifestyle risk factors, metabolic risk factors, and inflammatory bowel disease (IBD). Risk factor associations were assessed by linear and logistic regressions. Average annual percent change was calculated using joinpoint regression. Results: A total of 64,477 small intestinal cancer cases (age-standardized rate, 0.60 per 100,000) were estimated globally in 2020, with a higher disease burden found in North America (1.4). Higher small intestinal cancer incidence was associated with higher human development index; gross domestic product; and prevalence of smoking, alcohol drinking, physical inactivity, obesity, diabetes, lipid disorder, and IBD (β = 0.008–0.198; odds ratios, 1.07–10.01). There was an overall increasing trend of small intestinal cancer incidence (average annual percent change, 2.20–21.67), and the increasing trend was comparable among the 2 sexes but more evident in the older population aged 50–74 years than in the younger population aged 15–49 years. Conclusion: There was a substantial geographic disparity in the burden of small intestinal cancer, with higher incidence observed in countries with higher human development index; gross domestic product; and prevalence of unhealthy lifestyle habits, metabolic disorders, and IBD. There was an overall increasing trend in small intestinal cancer incidence, calling for the development of preventive strategies.
KW - Epidemiology
KW - Malignancy
KW - Small Bowel
UR - https://www.scopus.com/pages/publications/85166184312
U2 - 10.1053/j.gastro.2023.05.043
DO - 10.1053/j.gastro.2023.05.043
M3 - Article
C2 - 37277079
AN - SCOPUS:85166184312
SN - 0016-5085
VL - 165
SP - 600
EP - 612
JO - Gastroenterology
JF - Gastroenterology
IS - 3
ER -
SDG 3 Good Health and Well-being