Incidence and prevalence of hypoglycaemia in type 1 and type 2 diabetes individuals: A systematic review and meta-analysis

Hassan Alwafi, Alaa A. Alsharif, Li Wei, Dean Langan, Abdallah Y. Naser, Pajaree Mongkhon, J. Simon Bell, Jenni Ilomaki, Mansour S. Al Metwazi, Kenneth K.C. Man, Gang Fang, Ian C.K. Wong

Research output: Contribution to journalReview ArticleResearchpeer-review


Background: Previous meta-analysis investigating the incidence and prevalence of hypoglycaemia in both types of diabetes is limited. The purpose of this review is to conduct a systematic review and meta-analysis of the existing literature which investigates the incidence and prevalence of hypoglycaemia in individuals with diabetes. 

Methods: PubMed, Embase and Cochrane library databases were searched up to October 2018. Observational studies including individuals with diabetes of all ages and reporting incidence and/or prevalence of hypoglycaemia were included. Two reviewers independently screened articles, extracted data and assessed the quality of included studies. Meta-analysis was performed using a random effects model with 95% confidence interval (CI) to estimate the pooled incidence and prevalence of hypoglycaemia in individuals with diabetes. 

Results: Our search strategy generated 35,007 articles, of which 72 studies matched the inclusion criteria and were included in the meta-analysis. The prevalence of hypoglycaemia ranged from 0.074% to 73.0%, comprising a total of 2,462,810 individuals with diabetes. The incidence rate of hypoglycaemia ranged from 0.072 to 42,890 episodes per 1,000 person-years: stratified by type of diabetes, it ranged from 14.5 to 42,890 episodes per 1,000 person-years and from 0.072 to 16,360 episodes per 1,000-person years in type 1 and type 2 diabetes, respectively. 

Conclusion: Hypoglycaemia is very common among individuals with diabetes. Further studies are needed to investigate hypoglycaemia-associated risk factors.

Original languageEnglish
Article number108522
Number of pages15
JournalDiabetes Research and Clinical Practice
Publication statusPublished - 1 Dec 2020


  • Incidence
  • Meta-analysis
  • Prevalence
  • Type 1 diabetes
  • Type 2 Diabetes

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