In vivo tomographic velocimetry of the lung for the detailed study of lung disease and its treatments

Stephen Eric Dubsky, Stuart Brian Hooper, Karen Kit Wan Siu, Andreas Fouras

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Abstract

All lung disease dramatically alters the local motion of the lung during breathing. It stands to reason, therefore, that detailed measurement of lung motion could provide dramatic improvements in assessment of lung function. Using synchrotron-based phase contrast imaging, we have developed and applied tools for lung motion and function measurement. We demonstrate a low-dose alternative to traditional 4D-CT methods, capable of measuring instantaneous 3D tissue motion using only 6 projection images. Additionally, our technique provides estimation of the airflow distribution throughout the bronchial tree during the breathing cycle. The ability to measure lung function at a regional level will provide invaluable information for studies into normal and pathological lung dynamics, and may provide new pathways for diagnosis of regional lung diseases. Although proof-of-concept data were acquired on a synchrotron, the low-dose methodology developed lends itself to clinical scanning and offers translational opportunities.
Original languageEnglish
Title of host publicationProceedings of SPIE Volume 8506 - Developments in X-ray tomography VIII
EditorsStuart R Stock
Place of PublicationBellingham Washington USA
PublisherSPIE
Pages1 - 8
Number of pages8
Volume8506
ISBN (Print)9780819492234
DOIs
Publication statusPublished - 2012
EventSPIE Optics and Photonics 2012 - San Diego, United States
Duration: 1 Jan 2012 → …

Conference

ConferenceSPIE Optics and Photonics 2012
CountryUnited States
CitySan Diego
Period1/01/12 → …

Cite this

Dubsky, S. E., Hooper, S. B., Siu, K. K. W., & Fouras, A. (2012). In vivo tomographic velocimetry of the lung for the detailed study of lung disease and its treatments. In S. R. Stock (Ed.), Proceedings of SPIE Volume 8506 - Developments in X-ray tomography VIII (Vol. 8506, pp. 1 - 8). Bellingham Washington USA: SPIE. https://doi.org/10.1117/12.929465
Dubsky, Stephen Eric ; Hooper, Stuart Brian ; Siu, Karen Kit Wan ; Fouras, Andreas. / In vivo tomographic velocimetry of the lung for the detailed study of lung disease and its treatments. Proceedings of SPIE Volume 8506 - Developments in X-ray tomography VIII. editor / Stuart R Stock. Vol. 8506 Bellingham Washington USA : SPIE, 2012. pp. 1 - 8
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abstract = "All lung disease dramatically alters the local motion of the lung during breathing. It stands to reason, therefore, that detailed measurement of lung motion could provide dramatic improvements in assessment of lung function. Using synchrotron-based phase contrast imaging, we have developed and applied tools for lung motion and function measurement. We demonstrate a low-dose alternative to traditional 4D-CT methods, capable of measuring instantaneous 3D tissue motion using only 6 projection images. Additionally, our technique provides estimation of the airflow distribution throughout the bronchial tree during the breathing cycle. The ability to measure lung function at a regional level will provide invaluable information for studies into normal and pathological lung dynamics, and may provide new pathways for diagnosis of regional lung diseases. Although proof-of-concept data were acquired on a synchrotron, the low-dose methodology developed lends itself to clinical scanning and offers translational opportunities.",
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Dubsky, SE, Hooper, SB, Siu, KKW & Fouras, A 2012, In vivo tomographic velocimetry of the lung for the detailed study of lung disease and its treatments. in SR Stock (ed.), Proceedings of SPIE Volume 8506 - Developments in X-ray tomography VIII. vol. 8506, SPIE, Bellingham Washington USA, pp. 1 - 8, SPIE Optics and Photonics 2012, San Diego, United States, 1/01/12. https://doi.org/10.1117/12.929465

In vivo tomographic velocimetry of the lung for the detailed study of lung disease and its treatments. / Dubsky, Stephen Eric; Hooper, Stuart Brian; Siu, Karen Kit Wan; Fouras, Andreas.

Proceedings of SPIE Volume 8506 - Developments in X-ray tomography VIII. ed. / Stuart R Stock. Vol. 8506 Bellingham Washington USA : SPIE, 2012. p. 1 - 8.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

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Dubsky SE, Hooper SB, Siu KKW, Fouras A. In vivo tomographic velocimetry of the lung for the detailed study of lung disease and its treatments. In Stock SR, editor, Proceedings of SPIE Volume 8506 - Developments in X-ray tomography VIII. Vol. 8506. Bellingham Washington USA: SPIE. 2012. p. 1 - 8 https://doi.org/10.1117/12.929465